Taisho Pharmaceutical Co., Ltd.

Toyama Chemical Co., Ltd.

Tetsuya Tanikawa

Takaaki Ishii

Toru Yamaguchi

Masato Kashimura

Toshifumi Asaka

Tomohiro Sugimoto

Akiko Matsuura

Naoya Ono

Fumihito Ushiyama

Yasunobu Ushiki

Yasuhiro Tsutsui

Risa Tsuruta

Noritomo Fujino

Keiko Yamamoto

Ayumu Mori

An amidine compound represented by formula (I) (wherein Arepresents a nitrogen atom or a group represented by formula CR; Aand Aare the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; Rrepresents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; Rand Rare the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a Calkyl group, a Chaloalkyl group or a Calkoxy group; and Rand Rare the same as or different from each other and independently represent a hydrogen atom, a Chaloalkyl group, a Calkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

Amidine compound or salt thereof

An erythromycin A derivative represented by Formula

Erythromycin A derivatives

An erythromycin A derivative represented by the formula:

Erythromycin a derivatives

An erythromycin A derivative represented by the formula (I): ##STR1## �wherein R.sup.1 is a group represented by the formula: --OCOCH.sub.2 Y (wherein Y is a pyridyl group, a quinolyl group, a p-nitrophenyl group or a group represented by the formula: --NR.sup.4 R.sup.5 (wherein R.sup.4 and R.sup.5 may be the same or different, and are each a hydrogen atom, a methyl group, a pyridylmethyl, a quinolylmethyl group or a benzyloxycarbonyl group)) or a cladinosyloxy group, R.sup.2 is a hydrogen atom, or R.sup.1 and R.sup.2 together form an oxo group, R.sup.3 is a hydrogen atom, an acetyl group, an ethylsuccinyl group or a nicotinoyl group! or a pharmaceutically acceptable salt thereof has a strong antibacterial activity against not only Gram-positive bacteria but also some Gram-negative bacteria, in particular, Haemophilus influenzae which is a serious factor of infectious diseases in the respiratory organs.

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Tokyo, Japan

Tetsuya Tanikawa