Sumika Fine Chemicals, Co.,ltd.

Sumitomo Chemical Company, Limited

Tetsuya Shintaku

Nobushige Itaya

Kiyoshi Sugi

Kozo Matsui

Tadashi Katsura

Yoshihide Umemoto

Yoshikazu Kimura

A stabilizer composition comprising a phenyl acrylate compound or phosphite compound, and a sugar alcohol. A thermoplastic polymer composition comprising a phenyl acrylate compound or phosphite compound, and a sugar alcohol, wherein the total weight of the phenyl acrylate compound or phosphite compound, and the sugar alcohol is 0.001 to 3 parts by weight with respect to 100 parts by weight of the thermoplastic polymer.

Stabilizer composition

A polymer stabilizer comprising the following alkoxy compound:

Polymer stabilizer

The present invention relates to a crystal of bicalutamide having a defined form, as well as economical and industrially practical production methods of bicalutamide and a crystal thereof, which are superior in environmental benignity and safety. Accordingly, the present invention provides a production method of bicalutamide represented by the formula (I): which includes at least a step of reacting a compound represented by the formula (3): with an oxidizing agent, a production method of a crystal of bicalutamide, as well as a crystal form of bicalutamide as defined by X-ray diffraction (XRD) or solidC NMR measurement.

Crystal of bicalutamide and production method thereof

Production methods of imidazole compound and salt thereof and intermediates therefor

Production method of hydrazine derivative

A process for preparing tert-butyl 4&prime;-methyl-2-biphenylcarboxylate characterized in that 4&prime;-methyl-2-biphenylcarboxylic acid is reacted with isobutene in the presence of an acid catalyst. According to the present invention, tert-butyl 4&prime;-methyl-2-biphenylcarboxylate having high quality can be conveniently and industrially advantageously prepared in a high yield under mild reaction conditions such as ambient temperatures without complicated procedures or any hazardous solvents.

Process for producing tert-butyl 4&prime;-methyl-2-biphenylcarboxlate

A process for preparing a tert-alkyl carboxylic acid ester represented by the formula (III):

Process for preparing tert-alkyl ester from carboxylic acid

A series of compounds capable of deriving an intermediate for the production of compound (A) of the following formula,

2-phenylpyridine derivative and production method thereof

A series of compounds capable of deriving an intermediate for the production of a compound (A) of the following formula,

A series of compounds capable of deriving an intermediate for the production of a compound (A) of the following formula, ##STR1## which is an anti-HIV drug, and a production method thereof. To be specific, 4-(pyridin-2-yl)benzaldehyde hydrazone, a production method of this compound, and a production method from this compound to N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethyhidene]hydrazine. In addition, a salt of 2-(4-bromomethylphenyl)pyridine, 2-(4-dibromomethylphenyl)pyridine and a salt thereof, production methods of these compounds, and production methods to derive 4-(pyridin-2-yl)benzaldehyde which is a production intermediate for 4-(pyridin-2-yl)benzaldehyde hydrazone from these compounds.

A method of producing a 2-(p-alkylphenyl)pyridine compound economically, easily and industrially, which comprises adding manganese dioxide and trimethylchlorosilane, or adding manganese chloride to an organic ether solvent, and reacting p-alkylphenylmagnesium halide and 2-halopyridine in the obtained organic ether solvent.

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Osaka, Japan

Tetsuya Shintaku