Mie University

Biocomo Inc.

Tetsuya Nosaka

Koji Tanaka

Kazushi Kimura

Shujie Wang

Kousyoku Sai

Akira Mizoguchi

Kyosuke Tanaka

Aika Kaito

Masayuki Fukumura

Naoyuki Katayama

Mitsuo Kawano

Junpei Ohtsuka

Yuji Toiyama

Masato Tsurudome

Ken-ichiro Hara

Hidemasa Goto

Yuuhei Nishimura

Masahiko Sugimoto

Provided is a vital stain inspection method for distinguishing between cancer cells and normal cells within a lumen, or on the serous membrane side of an organ, by means of laser irradiation after organ tissue has been stained by curcumin, Red #3 or Red #106, which are edible color dyes.

Detection method

A cancer test device () is provided with: an application unit () for applying a staining agent (), which can selectively stain a product of a cancer-relating gene in a living cell a chromatic color, onto a group of living cells; an imaging unit () for imaging the group of living cells having the staining agent () applied thereto; and a determination unit () for determining the level of malignancy of cancerization of the group of living cells on the basis of the state of the stained expression pattern of the cancer-relating gene in the group of living cells in an image obtained by the aforementioned imaging.

Cancer test device, cancer test method, and staining agent for use in cancer test

Disclosed are: a virus vector in which a gene encoding an antigenic polypeptide is integrated in human parainfluenza virus type 2 gene, wherein the antigenic polypeptide is expressed in the form of a fusion protein with a viral structural protein; and a method for producing the same. The virus vector of the present invention contains a quantitatively large amount of the antigenic peptide on the virus particle and can efficiently deliver the antigenic polypeptide to a target cell.

Vaccine prepared utilizing human parainfluenza virus type 2 vector

The present invention discloses a cell system, as a host cell to be infected with an F gene-deficient virus, which can constitutively and stably express the F protein, and a method for producing an F gene-deficient virus by utilizing the cell. A non-proliferative human parainfluenza type 2 virus vector is produced by co-culturing an F gene-deficient human parainfluenza type 2 virus with a Vero cell having the F gene of human parainfluenza type 2 virus in such a manner that the F gene is non-inducibly expressed, and isolating viral particles from a culture supernatant.

Method for producing virus vector for gene transfer

Growing community of inventors

Mie, Japan

Tetsuya Nosaka