Banyu Pharmaceutical Co. Ltd

Msd K.k.

Tetsuya Kato

Mitsuru Ohkubo

Nobuhiko Kawanishi

Takashi Mita

Katsumasa Nonoshita

Yoshikazu Iwasawa

Hirobumi Takahashi

Osamu Okamoto

Takashi Yoshizumi

Hiroshi Kawamoto

Kensuke Kobayashi

Toshiyasu Shimomura

Satoru Itoh

Masanori Asai

Keita Nagai

Kouta Masutani

Yuichi Sugimoto

Hiroshi Miyazoe

Izumi Yamamoto

The present invention relates to a compound of formula I: wherein: Ris a hydrogen atom, F, CN, etc.; Ris CO, SO, etc.; Ris a phenyl which may be substituted; X, X, and Xeach independently CH, N, etc. provided, however, that among X, Xand X, the number of nitrogen is 0 or 1; W is the following residue: wherein: W, W, and Weach independently CH, N, etc., or a pharmaceutically acceptable salt or ester thereof. 

Aminopyridine derivatives having aurora a selective inhibitory action

The present invention relates to a compound of general formula I: wherein:

The present invention relates to a compound of formula I:  

Aminopyridine derivatives having aurora A selective inhibitory action

Provided are cycloalkanopyridine derivatives of formula [I]: [wherein the symbols are the same as those stated in the description]. The compounds act as a nociceptin receptor antagonist, and are useful as medicines for diseases associated with a nociceptin receptor, for example, as a reliever against tolerance to a narcotic analgesic; a reliever against dependence on or addiction to a narcotic analgesic; an analgesic enhancer; an antiobesitic or appetite suppressor; a treating or prophylactic agent for cognitive impairment and dementia/amnesia; an agent for treating developmental cognitive abnormality; a remedy for schizophrenia; an agent for treating neurodegenerative diseases; an anti-depressant or treating agent for affective disorder; a treating or prophylactic agent for diabetes insipidus; a treating or prophylactic agent for polyuria; or a remedy for hypotension.

Cycloalkanopyridine derivative

The present invention relates to a compound represented by the general formula (I): wherein mand mare 1, 2, or 3; nand nare 0 or 1; i is an integer of any of 1 to m; j is an integer of 1 to m; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rand R' is hydrogen atom, etc. and Rand R&#x2032; is hydrogen atom, etc.; R, R, and Rare hydrogen atom, etc; Xis CH, CX, or N; Xis CH, N, etc.; Xis CH, N, etc.; Xis CH or N; Y, Y, and Yare each independently CH or N; Zand Zare each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

Aminopyridine derivatives having Aurora A selective inhibitory action

This invention provides compounds which are represented by a general formula [I] [in which X stands for hydrogen or halogen; B stands for halogen, cyano or optionally fluorine-substituted lower alkyl; D stands for a 3&#x2013;10 membered aliphatic nitrogen-containing heterocyclic group; R, Rand Rmay be same or different, and each stands for hydrogen, lower alkyl optionally having substituent group(s) and the like; and a is 0 or 1]. These compounds exhibit high affinity to nociceptin receptors and whereby inhibit actions of nociceptin, and are useful as an analgesic, antiobestic, agent for ameliorating brain function, treating agents for Alzheimer's disease and dementia, and therapeutic agents for schizophrenia, neurodegenerative diseases, depression, diabetes insipidus, polyuria, hypotension and the like.

Benzimidazole derivatives

This invention relates to the compounds represented by a general formula [I]:[in which Aand Arepresent optionally fluorine-substituted methine or the like; B represents halogen, cyano, lower alkyl or the like; D represents optionally substituted heterocyclic group or the like; and G represents C-Caliphatic group such as alicyclic group]. These compounds inhibit nociceptin activities due to their high affinity to nociceptin receptor, and are useful as analgesic, antiobestic, corebral function improver, drugs for treatment of alzheimer's disease and dementia, remedies for schizophrenia and neurodegenerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, hypotension and so on.

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Tsukuba, Japan

Tetsuya Kato