Yanmar Co., Ltd.

Japan Tobacco Inc.

Minolta Camera Kabushiki Kaisha

Osaka University

Yanmar Power Technology Co., Inc.

Otsuka Pharmaceutical Company, Limited

Yanmar Holdings Co., Ltd.

Bikenbiomics Co., Ltd.

Tetsuya Iida

Yoshiaki Kuraya

Shinichi Kikuchi

Kiyoyuki Okuyama

Hiroyuki Abe

Toshiyuki Sakai

Mitsuru Takahashi

Takayuki Yamaguchi

Katsumi Fujiki

Toshitaka Komiya

Takashi Goto

Yoshikazu Hori

Hisashi Kawasaki

Kazuhide Hayakawa

Shimpachi Fushimi

Daisuke Motooka

Takayuki Yoshida

Shota Nakamura

Toyomichi Nanayama

Hironori Kurachi

Masahiro Tamaru

Kohji Nishida

Yutaka Matsui

Tadamitsu Uchiyama

Tomoya Miura

Takumi Hasegawa

Hiroyasu Yukino

Noriyasu Hashida

Shintaro Hirashima

Hiroyasu Ishida

Tomoyuki Manabe

Yasumitsu Tsujino

Kazunobu Asao

Satoru Ando

Michael Knoblett

Shunsuke Fukakusa

Toshio Kodama

Shigeaki Matsuda

Takahiro Maruno

Yuji Kobayashi

Tadayasu Ohkubo

Takuya Yoshida

Hiroya Oki

Kazuki Kawahara

Kentaro Sakurai

A method for detecting conjunctival diseases such as conjunctival MALT lymphoma, and an aging biomarker that serves as an indicator of the aging state of a subject are provided. The method for detecting conjunctival diseases comprises a step of comparing a microbial community structure of a microbiota in an ocular surface tissue specimen sampled from a healthy person with a microbial community structure of a microbiota in an ocular surface tissue specimen sampled from a subject to determine that the ocular surface tissue specimen of the subject has an indication of the conjunctival diseases. The aging biomarker a comprises bacterial species which belongs to the Corynebacteriaceae family or the Propionibacteriales family in an ocular surface tissue.

Method of detecting conjunctival disease using ocular surface tissue, and aging biomarker

A tractor includes an engine, a vehicle body, a rear PTO shaft, a central PTO shaft, a permission switch, and a control unit. The engine is configured to generate power. The vehicle body includes an operator's seat. The rear PTO shaft is configured to supply power generated by the engine to a rear work machine attached to a rear part of the vehicle body. The central PTO shaft is configured to supply power generated by the engine to a central work machine attached to a central part of the vehicle body. The permission switch is operable by an operator. The control unit indicates that the permission switch is operated as one of permission conditions for rotation of the rear PTO shaft after disembarkation, and indicates that the permission switch is operated as one of permission conditions for rotation of the central PTO shaft when moving backward.

Work vehicle

A work vehicle includes an driver's seat disposed in the rear region of a vehicle body, a left and a right fender that are disposed on the left and right laterally outward sides of the driver's seat, and a partition wall that divides, at a position behind the driver's seat, the vehicle body into a front region of the vehicle body on the front side of the partition wall and a rear region of the vehicle body on the back side thereof. Operation tools for operating working equipment provided on the vehicle body are disposed on one of the fenders, and the partition wall is provided offset toward a side where operation tools are disposed relative to the driver's seat.

A work vehicle includes a driver's step, a driver's seat disposed further rearward than the driver's step and between left and right rear traveling units, a steering wheel disposed in front of the driver's seat, left and right fenders that cover both of the rear traveling units from above; a boarding section that enables boarding and deboarding to and from the driver's step at a position on a front side of at least one of the fenders, and a gripping portion that is provided on a forward portion of the boarding section and is graspable to a driver when boarding and deboarding. The gripping portion is configured to have an inclined posture that is positioned further forward toward the outward side of the vehicle body, in a plan view.

Pyrazole compounds substituted with heteroaryl or pharmaceutically acceptable salts thereof that have an SGLT1 inhibitory activity and are useful for a drug, pharmaceutical compositions comprising the same, and pharmaceutical use thereof are disclosed. Specifically, a compound of Formula [X]: wherein Ris hydrogen or halogen, Ris Calkyl or halo-Calkyl, Ring Het is substituted pyridyl or optionally substituted pyrazinyl, pyrimidinyl, or pyridazinyl, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising it, and pharmaceutical use thereof is provided.

Pyrazole compounds substituted with heteroaryl and pharmaceutical use thereof

A peptide capable of preventing pathogenic bacteria from colonizing in digestive organs comprises a first domain having an amino acid sequence capable of binding to a minor pilin of IVb fimbriae, and a second domain having an amino acid sequence capable of multimerization, the second domain connect to the first domain via a linker sequence.

Peptide inhibiting colonization by pathogenic bacteria, and colonization inhibitor including same

A front loader including: a pair of masts provided to a machine body frame of a work vehicle in a detachable manner; a pair of lifting arms coupled to the masts in a vertically rotatable manner; and a work equipment mounted to the lifting arms. Each lifting arm includes a front lifting arm attached to one of the masts and a rear lifting arm attached to the work equipment, each of the front lifting arm and the rear lifting arm has a hollow, rectangular cross-section. The rear end portion of the front lifting arm is inserted into the front end portion of the rear lifting arm, and is welded. The side plate of the rear lifting arm at a location corresponding to the insertion portion has a protruding portion that extends along the side plate of the front lifting arm, and the protruding portion is welded.

Front loader and work vehicle equipped with the same

Front guard for a working vehicle

Front loader for a working vehicle

A tractor comprises a seat, a safety frame, a vehicle body frame, right and left attachment brackets, a front frame and a roof frame. The safety frame has two struts standing from right and left side portions rearward from the seat. The right and left attachment brackets are fixed on both right and left outer surfaces of the vehicle body frame. The front frame is formed in a gate shape in front view so as to have right and left lower portions detachably attached to the right and left attachment brackets. The roof frame is detachably attached so as to connect a right or left upper portion of the front frame to a right or left upper portion of the safety frame.

Tractor

The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.

Pyrimidine compound and medical use thereof

A tractor includes booms, lift cylinders, a hitch, dump cylinders, a magnetic valve, a speed-up circuit, and a speed-up restricting arm. The lift cylinders swing the booms upward and downward by an operating oil being supplied thereto. The hitch is provided to the booms to allow an implement to be attached thereto. The dump cylinders swing the implement upward and downward by the operating oil being supplied thereto. The magnetic valve switches between supplying the operating oil to the dump cylinders and supplying the operating oil to a grab cylinder provided in the implement. The speed-up circuit is able to perform a speed-up operation for increasing the flow rate of the operating oil supplied to the magnetic valve. The speed-up restricting arm is arranged near the speed-up circuit. The speedup restricting arm is brought into contact with a contact member attached to an input member for switching an operation of the speed-up circuit, to thereby restrict the speed-up operation, so that a speed-up of the grab cylinder is prevented.

A tractor includes a mounting plate, a protruding tube, a boom supporter, and a boom. The mounting plate is attachable to a frame on a side surface of a vehicle. The protruding tube is connected to the mounting plate, and shaped to protrude from a portion in which the protruding tube is connected to the mounting plate, toward the outside of the vehicle. The boom supporter is connected to a distal end portion of the protruding tube, and shaped to protrude upward from a portion in which the boom supporter is connected to the distal end portion of the protruding tube. The boom is coupled to the boom supporter via a boom coupler, and formed to extend from the boom coupler toward the front side of the vehicle. In a side view, an imaginary straight line extending vertically downward from the boom coupler is located rearward of the protruding tube.

Front loader

Growing community of inventors

Osaka, Japan

Tetsuya Iida