Adeka Corporation

Tokyo Medical and Dental University

The Chemo-sero-therapeutic Research Institute

Sapporo Medical University

Shimane University

Ibaraki University

Tetsuya Higami

Akio Kishida

Takanori Uchida

Haruki Obara

Naoki Morimoto

Tsuyoshi Kimura

Ken-ichiro Hiwatari

Toru Masuzawa

Noriko Shinya

Seiichi Funamoto

Kyohei Ochiai

Yu Yamaguchi

Jun Negishi

Kenichiro Hiwatari

Takuya Kimura

Mitsumasa Homma

Hideki Saga

Shoko Tokorozaki

Keita Kinoshita

A method of producing a decellularized transplantation material, wherein the method includes the steps of (a) harvesting a branch-bearing blood vessel from a vertebrate animal (a donor); (b) decellularizing the blood vessel; and (c) adhering, by a protein denaturation treatment, a portion where a branch has been excised to close the vessel. Also, a graft composition consisting of a biocompatible material that contains the decellularized transplantation material.

Method for producing decellularized material for transplantation and graft composition consisting of biocompatible material including said material

An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.

Anti-adhesion material and substitute biomembrane using decellularized tissue

An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.

Artificial blood vessel using decellularized blood vessel sheet

A devicefor bonding adherends Tand T, as a device for bonding biological tissue to biological tissue or a biological tissue bonding material, comprises: a clamping partfor clamping the adherends Tand Tbetween membersand; a pressing partfor pressing the membertowards the member; a pressure control partfor controlling the pressure by the pressing part; a heating elementbuilt into the member; a heating control partfor controlling the heating by the heating element; a vibration generating partfor generating microvibration; and a vibration control partfor controlling the microvibration generated by the vibration generating part

Biological tissue bonding device and biological tissue bonding medical instrument

Growing community of inventors

Sapporo, Japan

Tetsuya Higami