Adeka Corporation

Tokyo Medical and Dental University

The Chemo-sero-therapeutic Research Institute

Sapporo Medical University

Shimane University

Ibaraki University

Km Biologics Co., Ltd.

Tetsuya Higami

Akio Kishida

Takanori Uchida

Haruki Obara

Tsuyoshi Kimura

Ken-Ichiro Hiwatari

Naoki Morimoto

Ken-ichiro Hiwatari

Toru Masuzawa

Noriko Shinya

Yu Yamaguchi

Seiichi Funamoto

Kyohei Ochiai

Akiko Tasaki

Jun Negishi

Kenichiro Hiwatari

Hideki Saga

Keita Kinoshita

Mitsumasa Homma

Takuya Kimura

Shoko Tokorozaki

Satomi Harano

Junichi Matsuda

Sumika Miyabashira

A method of producing a decellularized transplantation material, wherein the method includes the steps of (a) harvesting a branch-bearing blood vessel from a vertebrate animal (a donor); (b) decellularizing the blood vessel; and (c) adhering, by a protein denaturation treatment, a portion where a branch has been excised to close the vessel. Also, a graft composition consisting of a biocompatible material that contains the decellularized transplantation material.

Method for producing decellularized material for transplantation and graft composition consisting of biocompatible material including said material

An anti-adhesion material comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing an anti-adhesion material comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; an anti-adhesion material kit comprising decellularized tissues and a biocompatible polymer or fibrin glue; a substitute biomembrane comprising decellularized tissues and a biocompatible polymer or fibrin glue; a method for preparing a substitute biomembrane comprising complexing a biocompatible polymer or fibrin glue to decellularized tissues; and a substitute biomembrane kit comprising decellularized tissues and a biocompatible polymer or fibrin glue.

Anti-adhesion material and substitute biomembrane using decellularized tissue

An artificial blood vessel that can be transplanted to blood vessels with a small diameter, can be adjusted to an arbitrary size of a diameter, improves in invasiveness when a graft is taken, and overcomes the problem on the provision of a graft is provided. An artificial blood vessel prepared from a decellularized tubular structure, which is prepared by processing a decellularized, sheet-like blood vessel (decellularized blood vessel sheet) into a roll structure, and a tissue adhesive, wherein a portion which is contacted with blood that flows within the artificial blood vessel consists of the tissue of the tunica intima lined with the tissue of the tunica media whereas a portion of the sheet that overlaps when the sheet is processed into a roll structure (overlap width) consists of the tissue of the tunica media and wherein a tissue adhesive is applied to the overlap width.

Artificial blood vessel using decellularized blood vessel sheet

A devicefor bonding adherends Tand T, as a device for bonding biological tissue to biological tissue or a biological tissue bonding material, comprises: a clamping partfor clamping the adherends Tand Tbetween membersand; a pressing partfor pressing the membertowards the member; a pressure control partfor controlling the pressure by the pressing part; a heating elementbuilt into the member; a heating control partfor controlling the heating by the heating element; a vibration generating partfor generating microvibration; and a vibration control partfor controlling the microvibration generated by the vibration generating part

Biological tissue bonding device and biological tissue bonding medical instrument

Growing community of inventors

Sapporo, Japan

Tetsuya Higami