Meiji Seika Kaisha, Ltd.

Neiji Seika Kaisha, Ltd.

Tetsutaro Niizato

Masaharu Shiotani

Takashi Tsuruoka

Shigeharu Inouye

Kiyoaki Katano

Tetsuya Matsushima

Takayuki Usui

Yukiko Hiraiwa

Naoto Ohkura

Shigeki Suzuki

Yuuko Nakatani

Chidsuko Kuroda

Yoko Shoji

Taro Niida

Takashi Shomura

Tomizo Niwa

Shoji Omoto

Takemi Koeda

Jiro Itoh

Nitrogen-containing heterocyclic compounds and therapeutic agents for hyperlipidemia comprising the same

Fosfomycin or a pharmaceutically acceptable salt thereof has been found to have an action of lowering the serum glucose level and is recognized to be useful as an orally administrable remedy for treating diabetes. It has further been found that the serum glucose level-lowering action of fosfomycin or its salt can be enhanced synergistically and significantly when forfomycin is administered in association with vanadyl sulfate and the like. Therefore,the composition comprising fosfomycin or its salt and vanadyl sulfate or the like is useful as an orally administrable remedy for treating diabetes.

Method for treatment of diabetes

Nitrogenous heterocyclic compounds and hyperlipemia remedy containing the same

Fosfomycin or a pharmaceutically acceptable salt thereof has been found to have an action of lowering the serum glucose level and is recognized to be useful as an orally administrable remedy for treating diabetes. It has further been found that the serum glucose level-lowering action of fosfomycin or its salt can be enhanced synergistically and significantly when fosfomycin is administered in association with vanadyl sulfate and the like. Therefore, the composition comprising fosfomycin or its salt and vanadyl sulfate or the like is useful as an orally administrable remedy for treating diabetes.

Composition for treatment of diabetes and treatment of diabetes

A new antibiotic SF-1130-x.sub.3 substance is produced by cultivating a microorganism Streptomyces myxogenes SF-1130 (deposited under FERM-P. 676 and ATCC 31305) in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the fermentation broth of said microorganism and is useful as an inhibitor to .alpha.-glucosidase and saccharase. Besides, this antibiotic, when orally given, is useful as a drug for suppressing an elevation in the level of blood sugar in living animals which have taken starch and/or sugars.

Antibiotic SF-1130-x.sub.3 3 substance and production and use thereof

D-glucaro-1,5-lactam and its pharmaceutically acceptable salts are useful as an agent of protecting against renal failure or damage induced by administration of aminoglycosidic antibiotics.

Agent for protecting against renal failure

Growing community of inventors

Yokohama, Japan

Tetsutaro Niizato