Ube Industries, Inc.

Sankyo Company, Limited

Sanko Co., Ltd.

Tetsushi Katsube

Tomio Kimura

Masayuki Iwata

Yoshimi Fujihara

Teruhiko Inoue

Masayuki Tanaka

Masahiko Hagihara

Noriaki Iwase

Eiji Okanari

Tomoko Kanda

Manabu Shigetomi

Shigeru Ushiyama

Hiroshi Fujiwara

Yoshiaki Kuroki

Tetsuo Kawaguchi

Koji Ito

Nobuhiko Shibakawa

Makoto Okudo

Kenji Yoneda

Ryo Iwamura

Yasunori Tokunaga

Hitoshi Ueno

Takashi Nishigaki

Takayuki Nakanishi

Ichiro Tanaka

Kiyoshi Yamamoto

The present invention provides a substituted biaryl compound of general formula (I): 

Substituted biaryl compound

The present invention provides a novel pyridylaminoacetic acid compound represented by the following formula (1): (wherein R, R, R, Y and Z are as defined in the description and claims), or a pharmacologically acceptable salt thereof. The pyridylaminoacetic acid compound has EP2 agonistic action and is therefore useful as a therapeutic and/or prophylactic agent for respiratory diseases such as asthma or chronic obstructive pulmonary disease.

Pyridylaminoacetic acid compound

The present invention discloses a pyrrolopyridazinone compound represented by the formula (1):  useful, for example, as an anti-inflammatory agent or an inhibitor of respiratory tract contraction.

Pyrrolopyridazinone compound

The present invention discloses a dibenzocycloheptene compound represented by the formula (I): 

Dibenzocycloheptene compound

This invention relates to a 8-trifluoromethylquinolinecaboxylic acid derivative represented by the following formula (I): ##STR1## (wherein R.sup.1 represents a lower alkyl group, a halogeno-lower alkyl group or a cycloalkyl group, R.sup.2 represents a phenyl group which may be substituted by R.sup.0, a 5-membered or 6-membered aromatic heteromonocyclic ring group containing 1 or 2 hetero atoms selected from N, O and S, which may be substituted by R.sup.0, or an aromatic heterocyclic fused ring group in which the said aromatic heteromonocyclic ring group and a benzene ring are fused, R.sup.0 represents a group selected from a halogen, a lower alkyl, a fluorine-substituted lower alkyl, a lower alkoxy or a lower alkylthio, R.sup.3 represents hydrogen or a lower alkyl group, and m represents an integer of 2 or 3.) or a pharmaceutically acceptable salt thereof or an ester thereof.

Trifluoromethylquinolinecarboxylic acid derivative

Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): ##STR1## wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.

Aryl group-or aromatic heterocyclic group-substituted aminoquinolone

Aryl group- or aromatic heterocyclic group-substituted aminoquinolone

Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy: R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.

4-oxoquinoline-3-carboxylic acid derivatives their preparation and their

Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.

Intermediates for certain 4-oxoquinoline-3-carboxylic acid derivatives

4-oxoquinoline-3-carboxylic acid derivatives and their use

Compounds of formula (I): ##STR1## (in which R.sup.1 is alkoxy, R is alkyl, haloalkyl, alkylamino, cycloalkyl or optionally substituted phenyl, X is chlorine or fluorine and Y is selected from certain specific heterocycles) have excellent antibacterial activity. They may be prepared by introducing the group represented by Y into the corresponding compound in which Y is replaced by a halogen atom.

Quinoline-3-carboxylic acid derivatives

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Ube, Japan

Tetsushi Katsube