Takasago International Corporation

Bristol-Myers Company

Bristol-Myers Squibb Compnay

Takasago International Coporation

Tetsuro Yamasaki

Takayuki Naito

Susumu Nakagawa

Haruhiro Yamashita

Taka-aki Okita

Hidenori Kumobayashi

Noboru Sayo

Takashi Aida

Hideo Kamei

Toshikazu Oki

Koji Tomita

Kenya Ishida

Hiroyuki Matsuda

Hajime Kamachi

Akira Amano

Seiji Iimura

Toshiyuki Murayama

Mitsuaki Tsunakawa

Shimpei Aburaki

Osamu Tenmyo

Makoto Harada

Noboru Sano

Hisao Iwai

Takero Ishizaki

Takeshi Yamamoto

Kazutoshi Sakurai

Tohru Yokozawa

Yoshifumi Yuasa

Tsukasa Sotoguchi

Kazuhiko Tokoro

Eiko Tamai

Miharu Ogura

Takeshi Ohnuma

Kenichiro Shiroyama

Xiaoyong Zhang

Tatsuya Omoto

Fragrance compositions containing 2-cyclohexyl-1,1-dimethyl ethanol esters

Trimethylcylohexane derivatives and melanin-formation inhibitors and perfumeholding agents with the use of the same

Keratin fiber strengthening agent and method for strengthening keratin fiber

An (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-ol represented by formula (I): ##STR1## wherein R represents an alkyl group having 1 to 3 carbon atoms, and a process for preparing the same comprising hydrogenating a corresponding (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-al in the presence of a ruthenium-phosphine complex as a catalyst, a base comprising an alkali metal or an alkaline earth metal, and an amine. The compound (I) has an excellent sandalwood oil odor.

(E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-ol,

An (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-ol represented by formula (I): wherein R represents an alkyl group having 1 to 3 carbon atoms, and a process for preparing the same comprising hydrogenating a corresponding (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-al in the presence of a ruthenium-phosphine complex as a catalyst, a base comprising an alkali metal or an alkaline earth metal, and an amine. The compound (I) has an excellent sandalwood oil odor.

(E)-(R)-2-alkyl-4-(2,2,3,-Trimethylcyclopent-3-en-1-yl)-2-buten-1-ol,

The present invention concerns neutral sugar derivatives of pradimicins, their use as antifungal agents, methods for their preparation, and intermediates for their synthesis.

Pradimicin derivatives

A novel chiral unsymmetric diphosphine compound of formula (I): ##STR1## wherein Ar.sup.1 and Ar.sup.2, which are different from each other, each represent a substituted or unsubstituted phenyl group, a substituted or unsubstituted naphthyl group, a pyridyl group, a quinolyl group, an isoquinolyl group, a furfuryl group, a benzofurfuryl group, a thienyl group, or a benzothienyl group, and a transition metal complex containing the diphosphine compound as a ligand. The complex catalyzes various asymmetric synthesis reactions, e.g., asymmetric hydrogenation or asymmetric hydrosilylation, exhibiting excellent performance in selectivity, conversion and catalytic activity, to provide a product of desired absolute configuration at high optical purity and in high yield.

Chiral unsymmetric diphosphine compound and transition metal complex

Disclosed herein is a process for producing a (2S,5S)-2,5-diamino-1,6-diphenyl-3-hexanone derivative represented by the formula (1): ##STR1## wherein R.sup.1 means a lower alkylcarbonyl group, a halogen-substituted lower alkylcarbonyl group, an arylcarbonyl group or a lower alkoxycarbonyl group, and R.sup.2 and R.sup.3 are identical with or different from each other and denote individually an aryl group or an alkoxy-substituted aryl group, which comprises subjecting a (2S)-2,5-diamino-1,6-diphenyl-4-hexen-3-one derivative represented by the formula (2): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meaning as defined above, to a hydrogenation reaction in the presence of a transition metal-containing catalyst.

Process for producing optically active diaminohexanone derivative

A process for preparing an optically active (2S,3S)-allophenylnorstatin derivative (I) is disclosed, comprising asymmetrically hydrogenating a 4-phenyl-2-halogeno-3-oxobutyric ester (III) in the presence of a ruthenium-phosphine complex to obtain a 4-phenyl-(2S)-halogeno-(3R)-hydroxybutyric ester (IV), epoxidizing the ester (IV) in the presence of a base to obtain a 4-phenyl-(2S,3R)-epoxybutyric ester (V), reacting the ester (V) with a tri(lower alkyl)silylazide or a (lower alkyl)diarylsilylazide in the presence of a Lewis to obtain a (3S)-azido-4-phenyl-(2S)-trisubstituted silyloxybutyric ester (VI), hydrogenolyzing the ester (VI) into a (2S,3S)-allophenylnorstatin derivative (VII), protecting the amino group of the compound (VII), and, if desired, hydrolyzing the compound before or after the amino group protection. Compounds (I) can be obtained at high optical purity safely and in good yield.

Process for preparing optically active allophenylnorstatin derivatives

A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive components designated BU-4224V A, B.sub.1, B.sub.2, and C. The components BU-4224V B.sub.1 and B.sub.2 display both antiviral and antimicrobial activity, while component BU-4224V A has antimicrobial activity and component BU-4224V C has antiviral activity.

Antiviral antibiotic BU-4224V

The present invention provides antitumor fluoro-substituted 4'-demethylepipodophyllotoxin glucosides.

Fluoro-substituted epipodophyllotoxin glucosides

A bronchodilating process employing purine derivatives '9-cyclohexyl-9H-adenine er 9-benzyl-2-n-propoxy-9H-adenine' is disclosed.

Bronchodilating process

Growing community of inventors

Kanagawa, Japan

Tetsuro Yamasaki