Asahi Kogaku Kogyo Kabushiki Kaisha

Laboratory Skin Care, Inc.

Asahi Kogaku Kogyo K.k.

Other

Tokyo Keiki Company Limited

Pentax Corporation

Toa Nenryo Kogyo Kabushiki Kaisha

Tao Nenryo Kogyo Kabushiki Kaisha

Asahi Kogaku K.k.

Kitana, Tadahiko

Nakayama, Mikio

Tetsuro Ogawa

Akihiko Yokoo

Takeshi Ichitsuka

Katsumi Kawamura

Masaya Sumita

Zahra Mansouri

Douglas W Thomas

Tsuneo Hiraide

Rodica-Tatiana Canelide

Nobuaki Tagaya

Takao Hashimoto

Tsugio Maeshima

Toshihiro Ishikawa

Akira Yamamoto

Yasuhiko Hirayama

Noriko Komatsu

Keiko Fukamachi

Hiroshi Okada

Ayumi Mitoh

Mikio Nakayama

Tadahiko Kitano

Yoshio Numaho

Sumiaki Tsuru

Yoshio Kato

Tadashi Kokubo

Hideyuki Kuwahara

Kiyoshi Arima

Satoshi Fujinuma

Takeshi Sakurai

Nobuo Nakabayashi

Satoshi Ojima

Masahide Inoue

Kazuhiro Naganuma

Makoto Ogiso

Shozo Koshikawa

Yukiko Gonda

Hideyuki Kuwakara

Aspects of the invention include sunscreen formulations that include uniform, rigid, spherical nanoporous calcium phosphate particles. Also provided are methods of making the sunscreen formulations. The sunscreen formulations find use in sunblocking applications.

Sunscreen compositions comprising uniform, rigid, spherical, nanoporous calcium phosphate particles and methods of making and using the same

Uniform, rigid, spherical nanoporous calcium phosphate particles that define an internal space and an amount of active agent present in the internal space are provided. Also provided are topical delivery compositions that include the active agent loaded particles, as well as methods of making the particles and topical compositions. The particles and compositions thereof find use in a variety of different applications, including active agent delivery applications.

Active agent loaded uniform, rigid, spherical, nanoporous calcium phosphate particles and methods of making and using the same

A bioactive glass having a composition substantially comprising 30 to 60 mol % of CaO, 40 to 70 mol % of SiOand 20 mol % or less of NaO has low glass transition temperature and/or crystallization temperature, and a sintered calcium phosphate obtained by using the bioactive glass as a sintering aid has excellent biocompatibility, mechanical strength and sinterability.

[object Object]

A bioactive glass having a composition substantially comprising 20 to 40 mol % of CaO, 40 to 60 mol % of SiO, and 10 to 20 mol % of MgO is high in bioactivity and mechanical strength, and a sintered calcium phosphate glass using the bioactive glass as a sintering aid is excellent in biocompatibility and mechanical strength.

Packing material for liquid chromatography and process for producing the same

A granular polymer composite comprising polymeric granules having coated on a surface thereof a calcium phosphate compound, at least a part of the particles of the calcium phosphate compound penetrates into the polymeric granules. The composite has a high bonding strength between the polymeric granules as a matrix and a coating of the calcium phosphate compound and also can fully exhibit the functions of a calcium phosphate compound. Using the granular polymer composite, a diagnostic agent which comprises of an antigen or antibody is adsorbed and immobilized on the composite and is therefore useful in diagnostic tests utilizing an antigen-antibody reaction for a number of infectious diseases.

Granular polymer composite and production process thereof as well as

In vivo-soluble composite particles involving a particle of a polymeric substance such as polylactic acid and the like soluble in a living body, having coated on a surface thereof, a calcium phosphate compound having a Ca/P ratio of about 1.0 to 2.0. The in vivo-soluble composite particles have a highly increased adsorptivity with regard to medicaments, antigens and others and also the in vivo-soluble composite particles can be dissolved or decomposed in the living body without producing a remainder in the body.

In vivo-soluble composite particles comprising calcium phosphate

A detection sheet capable of detecting an antigen or antibody in a biological fluid with a high sensitivity in a simple operation, as well as a detection kit and detection method using the detection sheet. The detection sheet comprises (a) a fibrous aggregate with carried particles of a calcium phosphate compound having an average particle diameter of about 0.01 to 200 microns and a Ca/P ratio of about 1.0 to 2.0, and (b) an avidin, streptavidin or avidin derivative from which carbohydrates have been extracted immobilized on said calcium phosphate compound. After a biotinylated antigen or antibody is bonded to the immobilized avidin, streptavidin, or avidin derivative of the detection sheet, the detection sheet is contacted with a test solution to thereby bond an antigen or antibody of the test solution to the detection sheet. The detection sheet is then contacted with a solution of labeling compound capable of being specifically bonded to the antigen or antibody of said test solution to detect the thus labeled antigen-antibody complex.

Sheets, kits and methods for detecting antigens or antibodies

A test plate for an agglutination test which comprises a plate with a plurality of wells formed thereon, each of the wells having adhered to a surface thereof a protein A and/or a protein G. The agglutination test plate, according to the present invention, when used in an agglutination test, can ensure a clear judgment concerning the formation of an agglutinative image or a non-agglutinative image, along with a good determination sensitivity. A process for the production of such an agglutination test plate is also provided.

Test plates for agglutination test and production process thereof

Column packing materials useful in applications such as liquid chromatography, as well as a process for producing such a packing material are described. A first aspect of the invention concerns a column packing material composed of a spherical substrate having a coating of a calcium phosphate based compound on the surface thereof. A second aspect of the invention concerns a packing material comprising porous calcium phosphate based granules having open pores with an average pore size of from 0.01 to 20 .mu.m, said granules being composed of crystalline particles with an average size of from 0.1 to 10 .mu.m. A third aspect of the invention concerns a spherical packing material for liquid chromatography comprising spherical particles of at least one material selected from the group consisting of Ca.sub.10 (PO.sub.4).sub.6 (OH).sub.2, Ca.sub.3 (PO.sub.4).sub.2, Ca.sub.2 P.sub.2 O.sub.7, Ca(PO.sub.3).sub.2, Ca.sub.10 (PO.sub.4).sub.6 F.sub.2 and Ca.sub.10 (PO.sub.4).sub.6 Cl.sub.2, said packing material having a dense stricture with a porosity of no more than 5%. A fourth aspect of the invention concerns a packing for liquid chromatography comprising particles having at least on the surface thereof a fluoroapatite represented by formula (I):

Packing material for liquid chromatography

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Tokyo, Japan

Tetsuro Ogawa