Central Glass Company, Limited

Toyama Prefecture

Tetsuro Nishii

Akihiro Ishii

Takashi Ootsuka

Yasuhisa Asano

Ayumi Yamaguchi

Naoki Sawai

Kenichi Fuhshuku

Ken-Ichi Fuhshuku

It is possible to produce an optically active fluoroalkyl chloromethyl alcohol with a high optical purity and a good yield by treating a fluoroalkyl chloromethyl ketone with a microorganism having an activity for asymmetrically reducing the ketone or an enzyme having the activity. Then, it is possible to obtain a fluoroalkyl ethylene oxide by treating the alcohol with a base. Industrial implementation of the production method of the present invention is easy.

Method for industrial production of optically active fluoroalkyl ethylene oxide

Disclosed is a method for producing (S)-1,1,1-trifluoro-2-propanol with high optical purity and high yield by having at least one kind of microorganism, which is selected from the group consisting ofand, act on 1,1,1-trifluoroacetone. Since microorganisms found in nature are made to act in a natural state, the problems to be raised when a transformant or the like is used can be avoided in this method. Consequently, the method can be easily put in industrial practice.

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Growing community of inventors

Kawagoe, Japan

Tetsuro Nishii