Japan, As Represented by the Director-general of National Institute of Infectious Disease

Dna Vec Research Inc.

Id Pharma Co., Ltd.

Tetsuro Matano

Makoto Inoue

Atsushi Kato

Mamoru Hasegawa

Yoshiyuki Nagai

Hiroto Hara

Tsugumine Shu

Munehide Kano

In this invention, a non-infectious particle has been produced, comprising a pathogen antigen protein caused to be expressed on the surface of a virus particle having at least one species of paramyxovirus envelope protein missing from the particle. This particle has been found to hold within the particle a large amount of antigen protein compared to an infectious particle, and to be capable of eliciting a host immune response with extremely high efficiency. The non-infectious particle according to the present invention is useful as a vaccine against a pathogenic virus, or the like.

Infectious disease vaccine using non-infectious paramyxovirus particle

The present invention provides a vaccine containing a Sendai virus vector encoding a virus protein of an immunodeficiency virus. By intranasally administering a Sendai virus encoding a virus protein of an immunodeficiency virus to a macaque monkey, the present inventors have succeeded in efficiently inducing protective immunity against an immunodeficiency virus. As a result of intranasal inoculation of vaccine, expression of an antigen protein mediated by Sendai virus vector was detected in intranasal mucous membrane and local lymph nodes and antigen-specific cellular immune response was induced at a significant level. No pathological symptom by vaccination was observed. After vaccination, exposure of simian immunodeficiency virus was performed and the effect was examined. As a result, the amount of virus in plasma significantly decreased, compared with that of the control animal. The present invention provides a promising vaccine as an AIDS vaccine.

AIDS virus vaccines using Sendai virus vector

Growing community of inventors

Tokyo, Japan

Tetsuro Matano