Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Bio Co., Ltd.

Other

Nihon University

Tetsuro Kuga

Seiga Itoh

Motoo Yamasaki

Makoto Morimoto

Kazuo Yamaguchi

Moriyuki Sato

Yoshiharu Yokoo

Masami Okabe

Hiromasa Miyaji

Yoshinori Komatsu

Hajime Yoshida

Satoshi Nakagawa

Tatsunari Nishi

Mikiko Sakurada

Tetsuyoshi Ishiwata

Shigemasa Sawada

Masami Takei

Susumu Sekine

Ayako Kawabata

Kenji Shibata

Akiko Furuya

Takahiro Nagase

Ayako Nishimura

Nobuo Nomura

Kazumi Araki

Hideji Hashida

Nanding Zhao

Yoshiyuki Sakaki

A novel DNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, methods for detecting the protein and the DNA, and methods of diagnosis and treatment of IgA nephropathy.

IgA nephropathy-related DNA

The present invention relates to a novel DNA related to IgA nephropathy obtained by a differential display method &lsqb; , 351, 231 (1994)&rsqb; taking note of an mRNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a method for detecting the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, a method for detecting the protein, and diagnosis and treatment of IgA nephropathy.

IGA nephropathy-related genes

The present invention relates to a novel protein isolated from the leukocyte of IgA nephropathy patients, and DNA encoding the protein. It also relates to an oligonucleotide based on the nucleotide sequence complementary with the DNA, an antibody which specifically reacts with the protein and, furthermore, diagnostic and therapeutic drugs of IgA nephropathy comprising it.

DNA encoding IGA nephropathy indicating protein

Novel hG-CSF polypeptide derivatives having an amino acid sequence derived from the amino acid sequence of the human granulocyte colony stimulating factor polypeptide by substitution of at least one amino acid by a different amino acid and/or deletion of at least one amino acid, recombinant plasmids containing a DNA fragment insert coding for any of these hG-CSF polypeptide derivatives, microorganisms carrying one of such plasmids, methods of producing the hG-CSF polypeptide derivatives using the microorganisms, a monoclonal antibody binding to the hG-CSF polypeptide derivative, and chemically modified hG-CSF or derivatives thereof are disclosed.

G-CSF conjugate

Method of producing a polypeptide having human granulocyte colony

The present invention relates to a DNA selected from DNAs, each having the nucleotide sequence of one of Sequence Nos. 1 to 17, complementary to the RNA strand of mRNA with the varied expression level in patients with Alzheimer's disease, compared with the expression level of the mRNA in normal human brain or a DNA hybridizable with the above-mentioned DNA wherein one or more nucleotides in said DNA are deleted or substituted with other nucleotides or one or more nucleotides are added to said DNA, a polypeptide encoded by the DNA, an antibody recognizing the polypeptide, and the diagnosis, therapeutic treatment and research works of patients with Alzheimer's disease, using the DNA, the polypeptide and the antibody.

DNA and protein for the diagnosis and treatment of Alzheimer's disease

Polypeptide derivatives of human granulocyte colony stimulating factor

DNA encoding human granulocyte colony stimulating factor plasmids and

The present invention provides a hybrid antigen polypeptide having both antigenicity of the ATLA encoded by gag gene and that of the ATLA encoded by env gene. The hybrid antigen can be produced in a large amount and it is applicable to serum diagnosis of patients infected with antigen polypeptides such as ATLV.

Method of producing an adult T cell leukemia virus fused antigen

Fused antigen polypeptide

L-histidine is produced by culturing, in a nutrient medium, an L-histidine producing mutant microorganism belonging to the genus Corynebacterium or Brevibacterium. The mutant is resistant to growth inhibition by an RNA polymerase inhibitor or requires adenine. L-histidine is accumulated in the culture liquor and is recovered therefrom.

Process for producing L-histidine by fermentation

Growing community of inventors

Yamaguchi, Japan

Tetsuro Kuga