The University of Texas System

Tetsuro Ikegami

Alexander N Freiberg

Clarence J Peters

Birte Kalveram

Olga Lihoradova

Shinji Makino

Sabarish Indran

Sungyong Won

Certain embodiments are directed to an improved RVF vaccine for human use, and method for producing the same.

Rift valley fever vaccine

Certain embodiments of the invention are directed to methods and compositions comprising a Rift Valley fever virus (RVFV) wherein a heterologous nucleic acid encoding a dsRNA-dependent protein kinase (PKR) inhibitor is inserted into the NSs region of the virus.

Recombinant rift valley fever virus encoding a dominant-negative inhibitor of DSRNA-dependent protein kinase in the NSS region

The present invention describes a reverse genetic system forsuch as Rift Valley fever virus. This system comprised of RNA expression plasmids and protein expression plasmids. Additionally, the present invention also discloses the modification of this system to generate a recombinant virus that expresses a non-viral foreign gene. Furthermore, the present invention discloses the use of this system in the development of anti-Rift Valley fever virus vaccines, screening of antivirals testing for anti RVF immune response and developing marker vaccines for Rift Valley fever virus. We also claim the utility of this approach to other.

Reverse genetic system for rift valley fever virus and uses thereof

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Galveston, TX, United States of America

Tetsuro Ikegami