Washington University

Oriental Yeast Co., Ltd.

Tetsuro Enomoto

Hideo Arai

Hisataka Yasuda

Jun Yoshino

Tatsuya Shinzato

An object of the present invention is to provide a material which can be safely ingested and which inhibits skin pigmentation. Therefore, the invention is a skin pigmentation inhibitor, containing a &#x3b2;-nicotinamide mononucleotide or a pharmaceutically acceptable salt thereof; and a solvate thereof as an active ingredient; a health supplement which contains the skin pigmentation inhibitor and is ingested to inhibit skin pigmentation; and a method for inhibiting skin pigmentation, including ingesting the skin pigmentation inhibitor.

Skin pigmentation inhibitor

The present disclosure provides for the administration of &#x3b2;-NMN, which increases the secretion of adiponectin. The present disclosure also provides an adiponectin secretion enhancer comprising &#x3b2;-nicotinamide mononucleotide, a pharmaceutically acceptable salt thereof or a solvate thereof, and a dietary supplement containing the aforementioned secretion enhancer, which can be ingested in order to increase the secretion of adiponectin. Also disclosed are methods of treating insulin resistance-related diseases such as of metabolic syndrome, diabetes, hyperlipidemia, fatty liver disease, hypertension, obesity, and arteriosclerosis.

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Tokyo, Japan

Tetsuro Enomoto