Teijin Limited

Nippon Oil Company

Tetsuo Toraya

Ichiro Kojima

Yasuhide Uejima

Katsuhiko Fujii

Yusuke Takahata

Atsuhiko Ishida

Mamoru Yamanishi

A novel hydrophobic vitamin B.sub.12 derivative represented by the formula: ##STR1## wherein R represents an alkyl group having 2 to 17 carbon atoms, and X represents a cyano group, a hydroxyl group, an alkyl group or a 5'-deoxyadenosyl group. Since the derivative is hydrophobic, it can be taken up by an organism by thermodynamic diffusion, a passive transport, without an active transport.

Hydrophobic vitamin B.sub.12 derivatives

Vitamin B.sub.12 compounds, salts and pharmaceutical compositions containing said compounds represented by formula (I): ##STR1## wherein L, a ligand to the cobalt of the corrin ring, is selected from the group consisting of a cyano or adenosyl group, B is an imidazole group or a 5,6-dimethylbenzimidazole group, and R is a straight alkylene group having 1 to 8 carbon atoms, are disclosed. Methods for preparing compounds of Formula (I) as well as methods for using the compounds in in vitro assays, in cell growth studies and in in vivo studies using transplanted murine tumor cells are disclosed.

Vitamin B.sub.12 derivative, preparation process thereof, and use thereof

Growing community of inventors

Okayama, Japan

Tetsuo Toraya