Taisho Pharmaceutical Co., Ltd.

Tetsuo Takayama

Naoya Ono

Tetsuya Yabuuchi

Fumiyasu Shiozawa

Masakazu Sato

Hironori Katakai

Hajime Asanuma

Takeshi Koami

Yoshinori Sekiguchi

Tomomi Ota

Makoto Yagi

Takahiro Oi

Fumihito Ushiyama

Yusuke Oka

Shoichi Kuroda

Yoshihisa Shirasaki

Rie Nishikawa

Masato Takahashi

Tsuyoshi Shibata

Yuki Shimizu

Makoto Hamada

Hideaki Amada

Masabumi Shibuya

Fumito Uneuchi

Madoka Kawamura

Hisaya Wada

Daisuke Wakasugi

Kenichi Kawabe

Daisuke Matsuda

Yuko Matsunaga

Akira Hiratate

Takehiro Yamagishi

Sota Kato

Chie Koizumi

Hiroki Umemiya

Akiko Ikeda

There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I&#x2032;),W, Y, R, R, R, and Yare as described hereinabove), or pharmaceutically acceptable salts thereof.

Partially saturated nitrogen-containing heterocyclic compound

Provided are novel compounds that bind to FKBP12 or pharmaceutically acceptable salts thereof, as well as new therapeutics useful in the prevention or treatment of alopecia which comprise those compounds or pharmaceutically acceptable salts thereof. Specifically, compounds represented by formula (1) [where Rrepresents either the following formula (2) or (3)] or pharmaceutically acceptable salts thereof are provided.

Azole derivative

A compound represented by formula (I) or a pharmaceutically acceptable salt thereof has an effect of inhibiting CRTH2 and, therefore, is useful as a preventive or a remedy for allergic diseases such as asthma, atopic dermatitis and allergic rhinitis.

Isoquinoline derivative

An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula &#x2014;SO&#x2014;, a group represented by Formula &#x2014;SO&#x2014;, or the like, Rrepresents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, Rrepresents a hydrogen atom or the like, Rrepresents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, Rrepresents an aryl group, Rrepresents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and Rrepresents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).

Triazole derivative

A compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof has an effect of inhibiting binding between S1P and its receptor Edg-1(S1P), and is useful as a pharmaceutical product. 

The present invention aims to provide compounds which have an inhibitory effect on the binding between S1P and its receptor Edg-1(S1P) and which are useful for pharmaceutical purposes. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: [wherein Ar represents a monocyclic heterocyclic ring containing one or two nitrogen atoms, A represents an oxygen atom or the like, Y, Yand Yeach represent a carbon atom or a nitrogen atom, Rrepresents a hydrogen atom, a C-Calkyl group or the like, Rrepresents a C-Calkyl group, a C-Ccycloalkyl group or the like, Rrepresents a C-Calkyl group or the like, Rrepresents a hydrogen atom or a C-Calkyl group, and Rrepresents a C-Calkyl group or the like].

Binding inhibitor of sphingosine-1-phosphate

A thiazolylimidazole derivative represented by the formula or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient,wherein:  The present invention provides an inhibitory substance against ALK5 which is a TGF-&#x3b2; type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.

Thiazole derivative

Aminobenzoic acid derivatives

Growing community of inventors

Toshima-ku, Japan

Tetsuo Takayama