Toray Industries, Inc.

Tetsuo Sudo

Yasuhiko Tanaka

Jun Utsumi

Hajimu Kurumatani

Katsuaki Kojima

Genji Kawano

Tatsutoshi Nakahata

Noriko Nakamura

Emiko Sano

Mizuo Matsui

Takatoshi Yamada

Gozoh Tsujimoto

Ryuhei Tanaka

Tetsuo Kubo

Atsushi Komiyama

The present invention provides SELF protein having controlling effects on growth and differentiation of undifferentiated cells, wherein the protein contains a novel EGF-like repeat sequence, SELF gene encoding the same, a recombinant vector and a transformed cell containing the SELF gene, a method for treatment or prophylaxis with SELF protein or a recombinant expression vector containing SELF gene, SELF promoter, a recombinant vector and a transformed cell containing SELF promoter, and a screening method using the transformed cell containing SELF promoter.

Protein having an EGF-like repeat sequence

A hemopoietic stem cell augmenting agent in which at least one type of hepatocyte growth factor is contained as an active component is provided. The hepatocyte growth factor has an augmenting activity on undifferentiated pluripotent hemopoietic stem cells and is useful as a hemopoietic stem cell augmenting agent for treatment of bone marrow suppression and for treatment of bone marrow malfunctions and furthermore is useful for in vitro growth of peripheral blood stem cells and bone marrow stem cells. Furthermore, a hepatocyte growth factor derived from human normal fibroblasts which is considered to be a type of hepatocyte growth factor can be obtained by genetic recombination techniques, and said factor is also useful as a hemopoietic stem cells augmenting agent.

Hemopoietic stem cell multiplier

Method for treating ophthalmic diseases

Hematopoietic stem cell growth-promoting compositions containing a

Growing community of inventors

Fujisawa, Japan

Tetsuo Sudo