Daiichi Seiyaku Co., Ltd.

Toyo Boseki Kabushiki Kaisha

Takara Shuzo Co., Inc.

Daiichi Pharmaceutical Co., Ltd.

Shin-etsu Chemical Co., Ltd.

Takeda Chemical Industries, Inc.

Tsumura Co., Ltd.

Tokyo Metropolitan Institute for Neurosciences

Tetsuo Shiba

Ikunoshin Kato

Naoyuki Taniguchi

Yuichi Yamamura

Tsuneo Kusama

Kaoru Inami

Shusaku Yanagidani

Naofumi Uozumi

Kazutoh Takesako

Tsunehiko Soga

Toru Kurome

Hidemasa Ogawa

Shozo Kotani

Koichi Shudo

Nobuto Koyama

Eiji Kobayashi

Ichiro Azuma

Tatsuhiko Hongu

Yuji Tokushige

Shoichi Kusumoto

Terumi Nakajima

Nobufumi Kawai

Tadamasa Hirayama

An isolated, porcine &#x3b1;1-6 fucosyltransferase having the following physico-chemical properties:

&#x3b1;1-6 fucosyltransferase

&agr;1-6 fucosyltransferase

A cyclopentenone derivative represented by the following formula [I] or an optically active substance or a salt thereof. ##STR1## (In the formula, R.sub.1 and R.sub.2 are same or different and each of them is straight or branched alkyl group, straight or branched alkenyl group, aromatic group, aromatic-aliphatic group or H with a proviso that the case where R.sub.1 =R.sub.2 =H, or R.sub.1 =benzyl group and R.sub.2 =H is excluded.)

Cyclopentenone derivative

.alpha.1-6 fucosyltransferase

To provide a process for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. A process for synthesizing a cyclic peptide represented by the following formula (I): ##STR1## wherein X1, X2, X4 and X7 are independently N-methyl-.alpha.-amino acid or .alpha.-hydroxy acid,

Cyclic peptides

A process is provided for the total synthesis of a cyclic peptide, which is useful as antifungal drug, and novel compounds prepared by the synthesis method. The cyclic peptide is represented by the following formula (I): ##STR1## wherein X1, X2, X4 and X7 are independently N-methyl-.alpha.-amino acid or .alpha.-hydroxy acid,

Process for systhesizing cyclic peptides

A disaccharide compound represented by formula (I): ##STR1## wherein R, R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are as defined in the specification and a salt thereof are disclosed. The compound exhibits excellent antitumor activity and low toxicity and is useful as an antitumor agent.

2-Deoxy-2-aminoglucopyranoside derivatives

Disaccharide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 CO-- and R.sup.2 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms and having a hydroxyl group at the 3-position thereof; R.sup.3 CO-- and R.sup.4 CO-- each represents a residue of a straight chain fatty acid having from 8 to 20 carbon atoms; and m and n each represents an integer of from 8 to 12, and the salts thereof. The compounds exhibit biological activities equal to or higher than those of natural lipid A. Also, the compounds of this invention are very useful as standard reagent for determination of endotoxin in the samples to be tested.

Process for preparing a disaccharide derivative

An antibacterial substance comprising a peptide comprising a fragment constituting lepidopteran A and containing the N-terminal amino acid residue of the lepidopteran A, wherein the carboxyl group at the C-terminal of said peptide is substituted with an alkyl amide group represented by Formula (I):

Antibacterial substance

Phosphorus containing disaccharide derivatives

A compound of the formula ##STR1## wherein R' is hydrogen atom or an alkyl group, m is an integer of 1 to 3, p is 1 or 2, x is an integer of 2 to 6, and y is an integer of 1 to 3, or a salt thereof, which has glutamate receptor inhibitor activity, a process for preparing the same and an insecticidal composition containing the same are provided.

Glutamate receptor inhibitor and insecticidal composition

A method for treating and preventing bacterial infections which comprises administering a 6-O-acylmuramyl depeptide of the formula: ##STR1## wherein X represents a divalent residual group of an amino acid such as L-alanine, L-serine, L-valine, etc., Y represents a residual group of a middle to higher fatty acid having 10 to 60 carbon atoms and isoGln represents a residual group of isoglutamine, or a pharmaceutical composition containing a 6-O-acylmuramyl dipeptide of the formula(I) as an active ingredient to a patient afflicted therewith.

Method for treating and preventing bacterial infections

Muramyldipeptide derivatives of the formula (I): ##STR1## wherein X represents an amino acid residue such as of L-alanine, L-serine, L-valine, glycine, etc., and Y represents a group ##STR2## wherein R.sub.1 represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms, a carboxamide group or a carboxyl group, n represents an integer of 1 to 6, A represents a straight or branched chain, saturated or unsaturated aliphatic hydrocarbon residue of 7 to 30 carbon atoms, and 'Acyl' means an acyl group of an aliphatic carboxylic acid having 2 to 6 carbon atoms. These compounds have excellent adjuvant activity and/or prophylactic and therapeutic effects against microbial infections.

Muramyldipeptide derivatives

Muramyldipeptide derivatives of the formula: ##STR1## wherein Y represents a mycoloyl group or a synthetic higher acyl group having total carbon number of C30-C90 and having at least a branched chain of long alkyl group on the .alpha.-position thereof,

Muramyldipeptide derivatives and process for the preparation thereof

Growing community of inventors

Toyonaka, Japan

Tetsuo Shiba