Sumitomo Chemical Company, Limited

Sumitomo Pharmaceuticals Company Limited

Tetsuo Noguchi

Yoshiya Yamahira

Makoto Sunagawa

Keiji Fujioka

Shigeji Sato

Haruki Matsumura

Yukio Ozaki

Takeshi Noguchi

Fumio Samizo

Akira Uemura

Chikako Matsusaka

Katsuhiko Shima

Yutaka Takeuchi

Yutaka Isobe

A preparation obtained by coating granules containing both a basic medical agent hydrochloride (e.g. allotinolol hydrochloride) and a polyanion the particles of which are present in the form of a discontinuous layer, with a film containing a slightly water-soluble substance, can release said agent at a controlled rate without influenced by the physiological factors of the gastrointestinal tract of a patient when orally administered.

Sustained-release prepararation of basic medical agent hydrochloride

(4R,5S,6S 8R,2'S,4'S)-3-[4-(2-Dimethylaminocarbonyl)pyrrolidinylthio]-4-methyl-6-(1- hydroxyethyl)-1-azabicyclo[3.2.0]hept-2-en-7-one-2-carboxylic acid of the formula: ##STR1## in a crystalline form, which is useful as an antibiotic agent.

Carbapenem compound in crystalline form, and its production and use

An antiinflammatory cream preparation which comprises an antiinflammatory substance hardly soluble in water in a base composition at a concentration of 0.05 to 1.5% by weight based on the preparation, the base composition comprising a medium chain fatty acid triglyceride of which the fatty acid has 6 to 12 carbon atoms, carboxyvinyl polymer and purified water in a weight proportion of 1-25:0.3-3:75-99, and with an adjusted pH of 4 to 10. The cream preparation is excellent in the availability of the antiinflammatory substance contained therein and advantageously is low in stimulation and high in safety.

Cream Preparation

A composition comprising as the pharmaceutically active ingredient bencyclane fumarate and cyclodextrin. As compared with prior bencyclane fumarate preparations, this composition can greatly decrease the adverse effects of bencyclane fumarate and, in addition, offers considerable advantages from the viewpoints of method of use and method of production of preparation.

Pharmaceutical composition comprising bencyclane fumarate and

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Suita, Japan

Tetsuo Noguchi