Aderans Company Limited

Japan Science and Technology Agency

Taiho Pharmaceutical Company Limited

Tetsuo Noda

Yoshihiro Yoneda

Hiroshi Maeda

Osamu Asakura

Naoyuki Fujita

Yutaka Shirakashi

Michinobu Fujiwara

Hiroshi Kakiuchi

Setsuo Fukuhara

Masakazu Fukushima

Takashi Kadowaki

Toshimasa Yamauchi

Ryozo Nagai

Yasushi Imai

Tetsuya Kubota

Naoto Kubota

Yasuo Terauchi

Hiroaki Tsujimoto

A scavenger receptor A expression down-regulator and a drug for preventing or treating arteriosclerosis which contain, as the active ingredient, a C-terminal globular domain of adiponectin, adiponectin, or a gene encoding the domain or adiponectin. According to the present invention, there is provided a preventive or therapeutic agent capable of directly preventing intimal thickening, which constitutes an essential feature of arteriosclerosis. This effect can be attained through arresting the onset and development of arteriosclerosis by reducing the expression level of scavenger receptor A in arterial walls and preventing lipid buildup in macrophages.

Method for treating arteriosclerosis

Non-human animals deficient in a function of a uridine phosphorylase gene on a chromosome, and their offspring. These non-human animals and their offspring make it possible to elucidate pathologic functions and activities of nucleic acid dysbolism and the like and also to predict utility of pyridine nucleoside antimetabolites in human, and are useful as experimental animals.

Animals with insufficient expression of uridine phosphorylase

A synthetic fiber having an uneven surface structure consisting of wrinkles having ridges and recesses of the surface of the fiber and not presenting specular luster, which may be used, for example, as artificial hair for wigs, can be produced easily and stably by melt-spinning a starting synthetic resin such as nylon and passing the spun monofilament through a cooling bath at a temperature not lower than 30.degree. C. for a period of time sufficient for developing wrinkles in its surface. Inclusion of a pigment such as carbon black in an appropriate amount in the starting material is effective in providing dense distribution of wrinkles.

Synthetic fibers having uneven surfaces method for melt-spinning

A synthetic fiber having an uneven surface structure consisting of wrinkles having ridges and recesses of the surface of the fiber and not presenting specular luster, which may be used, for example, as artificial hair for wigs, can be produced easily and stably by melt-spinning a starting synthetic resin such as nylon and passing the spun mono-filament through a cooling bath at a temperature not lower than 30.degree. C. for a period of time sufficient for developing wrinkles in its surface. Inclusion of a pigment such as carbon black in an appropriate amount in the starting material is effective in providing dense distribution of wrinkles.

Synthetic fibers having uneven surfaces and a method of producing same

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Tokyo, Japan

Tetsuo Noda