The University of Tokyo

Other

Daiichi Pure Chemicals Co., Ltd.

Sekisui Medical Co., Ltd.

Mitsubishi Rayon Company, Limited

Shionogi Company Limited

Tohoku University

Tetsuo Nagano

Japan Science and Technology Agency

Riken Corporation

Jasco Corporation

Syoryukensetsu Corporation

Nagano, Tetsuo

Yasuteru Urano

Hirotatsu Kojima

Kazuya Kikuchi

Kenjiro Hanaoka

Tomoya Hirano

Takahiro Egawa

Takayoshi Okabe

Yuichiro Koide

Kazuhisa Hirabayashi

Masayo Sakabe

Fujio Yu

Nobuyuki Tanaka

Osamu Nureki

Mako Kamiya

Hiroshi Nishimasu

Ryuichiro Ishitani

Yusuke Tateno

Junken Aoki

Daisuke Asanuma

Kenzo Hirose

Takuya Myochin

Yu Kushida

Junji Yamane

Takuji Shoda

Suguru Kenmoku

Ken-ichi Setsukinai

Tomoe Ohta

Mitsuyasu Kawaguchi

Saki Izumi

Kazuki Kiyose

Takuya Matsumoto

Shigeyuki Yokoyama

Hirofumi Nakano

Akiko Tanaka

Manabu Katou

Hiroshi Hayakawa

Shiro Kida

Hidenori Ichijo

Yasuhiko Kanda

Masanao Abe

Takao Fujisawa

Chiaki Fujikoshi

Norihiro Kokudo

Keiko Tsuganezawa

Sakae Higashidate

Tsunehiko Higuchi

Takeaki Ishizawa

Teruki Honma

Hitomi Yuki

Eita Sasaki

Yoshiyuki Kioi

Kensuke Komatsu

Hideo Takakura

Kohjiro Kanda

Shinya Iwasawa

Shigeyuki Namiki

Yousuke Takaoka

Masamitsu Iino

Naoki Umezawa

Masaaki Hirobe

Naomi Tsuburaya

Tsuneaki Sugimoto

Norio Shiibata

Wen Piao

Seiichi Nakamura

Hidehiko Nakagawa

Shin-Ichi Ikeda

Suguru Yamashita

Yuko Toki

Takanari Inoue

Manabu Shimonishi

Yu Kagami

Nae Saito

Yu Gabe

Yasunobu Hirata

Koji Numasawa

Sakiko Aizawa

Masahide Odan

Masahiro Abo

Kengo Homma

Rie Tomiyasu

Tasuku Ueno

Masahiro Simoda

Toru Komatsu

Satoru Konno

Ken-Ichi Setsukinai

Fluorescent probes and their salts have high fluorescence quantum yield and high resistance to photobleaching suitable for visualizing various pH environments within cells such as weakly basic, neutral, and weakly acidic environments. The fluorescent probes can have the following structure: 

pH sensitive fluorescent probe

A compound represented by the following formula (1) is provided: wherein X represents a sulfur atom or &#x2014;CH&#x2550;CH&#x2014;; Ato Aeach independently represent a carbon atom or a nitrogen atom, and at least one of Ato Ais a nitrogen atom; Rrepresents any one of a 1,2,3,4-tetrahydroquinolyl group (or a 3,4-dihydro-1(2H)-quinolyl group), a 3,4-dihydro-4,4-dimethyl-1(2H)-quinolyl group, a 2,3,4,5-tetrahydro-1H-1-benzazepinyl group, or a substituent represented by the following formula (2): wherein Rrepresents a 2,3,4-trifluorophenyl group, a 4-iodophenyl group, a 2,3-difluorophenyl group, a 3,5-difluorophenyl group, a 5-fluoro-2-methylphenyl group, a 3-pentafluorosulfanylphenyl group, a 2,6-dimethylphenyl group, a 4-benzyloxyphenyl group, a 3,5-bis(trifluoromethyl)biphenyl group, a 4-tert-butylphenyl group, a 3-methoxyphenyl group, an unsubstituted or substituted pyridyl group, or an unsubstituted or substituted naphthyl group; Rrepresents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group optionally containing an oxygen atom and/or a double bond, or an unsubstituted or substituted aromatic lower alkyl group; Rrepresents a hydrogen atom, a lower alkyl group, a lower acyl group, or an unsubstituted or substituted aromatic lower alkyl group; and Rrepresents a hydrogen atom, or Rand Rmay bind to each other to form a ring.

Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof

The present invention provides a compound of formula (1), wherein R, R, R, R, R, Rand Rare as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound. 

Fused pyrazole derivative having autotaxin inhibitory activity

A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: 

Pyrimidinone derivative having autotaxin-inhibitory activity

[Problem] To provide a novel near-infrared quencher. [Solution] A compound represented by general formula (I) or a salt thereof. 

Near-infrared quenching group

Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure.  In the formula, Rand Rindependently represent a hydrogen atom, or an alkyl group which may be substituted (wherein Rand/or Rrepresents an alkyl group which may be substituted); R, R, R, R, Rand Rindependently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.

Acidic environment-detecting fluorescent probe

[Problem] To provide: a compound resulting from substituting with a silicon atom the oxygen atom at position 10 of a xanthene ring site of a rhodamine of which amino groups at position 3 and position 6 have an asymmetrical structure; a method for producing the compound; and a fluorescent probe that uses the compound. [Solution] The compound represented by general formula (I) or a salt thereof. 

Asymmetrical Si rhodamine and rhodol synthesis

A compound represented by the formula (I) (Rrepresents hydrogen atom or a monovalent substituent; Rand Rrepresent hydrogen atom, an alkyl group, or a halogen atom; Rand Rrepresent an alkyl group or an aryl group; Rand Rrepresent hydrogen atom, an alkyl group, or a halogen atom; Rrepresent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer.

Fluorescent probe

Methods for identifying the presence of cancerous cells or tissue by: applying a compound of formula (I), or salts thereof, to a living body, wherein Rrepresents hydrogen or the same or different one to four substituents; R, R, R, R, R, and Rindependently represent hydrogen, hydroxy, alkyl, or halogen; Rand Rindependently represent hydrogen or alkyl; and X represents C-Calkylene; and detecting fluorescence emitted by a compound of formula (II), wherein R, R, R, R, R, R, R, R, and Rare as defined above; wherein fluorescence emitted by a compound of formula (II) is indicative of the presence of cancerous cells or tissue.

Method for diagnosing cancer

A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; Rrepresents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R, R, R, R, R, and Reach independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; Rand Reach independently represent a hydrogen atom or an alkyl group; and X represents a C-Calkylene group).

Fluorescent probe for high-sensitivity pancreatic fluid detection, and method for detecting pancreatic fluid

A compound represented by the formula (I) (Rrepresents a substituent on the benzene ring; Rrepresents a monovalent substituent; Rand Rrepresent hydrogen atom, or an alkyl group; Rand Rrepresent an alkyl group, or an aryl group; Rand Rrepresent hydrogen atom, or an alkyl group; Rand Rrepresent hydrogen atom, or a monovalent substituent; and X represents silicon atom, germanium atom, or tin atom), or a salt thereof. 

A compound represented by the formula (I) [Rrepresents hydrogen atom or a substituent; R, R, R, and Rrepresent hydrogen atom, an alkyl group, a halogen atom, or a hydrophilic substituent; Rand Rrepresent an alkyl group or an aryl group; Rand Rrepresent a group cleaved by contact with an object substance for measurement; and X represents silicon atom, germanium atom, or tin atom] or a salt thereof, which is useful as a fluorescent probe that emits red fluorescence by contact with an object substance for measurement. 

A compound represented by the formula (I) (one of substituents represented by Ris a trapping group for an object substance for measurement; Rand Rrepresent hydrogen, alkyl, or halogen; Rand Rrepresent alkyl or aryl; Rand Rrepresent hydrogen, alkyl, or halogen; Rrepresents hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl, and X represents silicon, germanium, or tin, which can be used as a fluorescent probe that enables red color bioimaging using intramolecular photoinduced electron transfer. 

An anticancer agent comprising a compound represented by the formula (I) [Rrepresents hydrogen atom, hydroxyl group, a Calkoxy group and the like; Rand Rrepresents hydrogen atom, a halogen atom, a Calkyl group and the like; Rrepresents hydrogen atom, a Calkyl group, a Calkylsulfonyl group and the like; Rrepresents hydrogen atom or a substituent;represents a single bond or a double bond; Rand Rrepresents hydrogen atom, a Calkyl group and the like; Rrepresents hydrogen atom, a Calkyl group and the like; A represents &#x2014;O&#x2014;, &#x2014;S&#x2014;, or &#x2014;CH&#x2014;; D represents &#x2014;C&#x2550; or &#x2014;N&#x2550;; X represents methylene group, &#x2014;O&#x2014;, or &#x2014;CO&#x2014;; Q represents &#x2014;N&#x2550; or &#x2014;C(R)&#x2550;; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase. 

Anticancer agent

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Tokyo, Japan

Tetsuo Nagano