Sankyo Company, Limited

Tetsuo Miyadera

Shinichi Sugawara

Yukio Sugimura

Teruo Tanaka

Kimio Iino

Toshihiko Hashimoto

Tomoyuki Shibata

Atsusuke Terada

Mitsuo Nagano

Syunji Naruto

Toshiharu Kamioka

Ryuji Tachikawa

Compounds of formula (I): ##STR1## (wherein R.sup.1 is carboxy, --CONR.sup.4 R.sup.5, cyano or hydroxymethyl, and R.sup.2 and R.sup.3 are hydrogen, alkyl or substituted alkyl, R.sup.4 and R.sup.5 being hydrogen or a variety of groups) have good antibiotic activity and reduced renal toxicity.

Carbapenem compounds and use

Compounds of formula (I): ##STR1## in which: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;

2-penem-3-carboxylic acid derivatives and use

Compounds of formula (I): ##STR1## (wherein R.sup.1 represents a C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 alpha-hydroxyalkyl group;

Penem derivatives, and composition containing them

Compounds of formula (I): ##STR1## [wherein: R.sup.1 represents a hydrogen atom, an alkyl group, an alkoxy group or various substituted alkyl groups;

Carbapenem compounds, and compositions containing them

Novel cephalosporin derivatives having a (1-alkyl-1H-tetrazol-5-yl)vinyl group at the 3-position of the cephem nucleus and showing an excellent antibacterial activity are disclosed. A process for preparing the cephalosporin derivatives is also disclosed.

7-D-(-)-mandelamido-3-(1-methyl-1H-tetrazol-5-yl)vinyl-

Aminoalkanol derivatives having the formula ##STR1## wherein R.sub.1 represents hydrogen atoms or a halogen atom, R.sub.2 represents hydrogen atom or fluorine atom and A represents an alkylene group having 1-4 carbon atoms. The aminoalkanol derivatives are useful as a minor tranquilizer and can be prepared by reacting the corresponding 2-amino-.alpha.-phenylbenzylideneaminoalkanol derivative with an aminocarboxylic acid.

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Tokyo, Japan

Tetsuo Miyadera