Takeda Pharmaceutical Company Limited

Takeda Chemical Industries, Inc.

Fujicopian Co., Ltd.

Tetsuo Hoshino

Kazuhiro Saito

Tomomichi Futo

Masuhisa Hori

Susumu Iwasa

Jun Sogabe

Shigehisa Taketomi

Kazumichi Yamamoto

Yasutoshi Inoue

Venkata R Garigapati

Yoshiyuki Asabe

Susumu Arauchi

Amit Garle

Osamu Ogiyama

Hiroya Muranishi

The present application provides a semi-permeable hydrogel composition comprising an alginate matrix that is covalently crosslinked in its periphery to a multi-armed water soluble polymer, along with related methods and uses thereof.

Alginate hydrogel compositions

Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt % to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drug sustained-release over a long period of time, and method for producing the same.

Sustained-release composition and method for producing the same

A process for producing a sustained-release composition which comprises mixing an aqueous solution containing a physiologically active substance and an acid or base in a molar amount of 1.5 or more times that of the physiologically active substance with a solution of a biodegradable polymer and then drying the mixture is provided.

Process for producing sustained-release composition

A sustained release preparation comprising a combination of a microcapsule which gradually releases a GnRH agonist or a salt thereof for a long term, and a microcapsule which gradually releases a GnRH agonist or a salt thereof for a short term.

Sustained-release preparations

Thermal transfer recording medium

An apatite-coated solid composition which contains a biodegradable polymer and an apatite-coated solid composition which contains a biodegradable polymer and a medicinal substance have properties of sustained release and of osteoconductive activity.

Apatite-coated solid composition

This invention provides a pharmaceutical composition comprising a non-peptide osteogenesis-promoting substance and a polyethylene glycol or a derivative thereof, which can be advantageously used as a agent for preventing or treating various bone diseases (e.g., osteoporosis) in view of the high oral absorbability and stability of the active ingredient.

Pharmaceutical composition containing osteogenesis-promoting substance

This invention provides a pharmaceutical composition comprising a non-peptide osteogenic promoting substance and a biodegradable polymer, which can be safely used as a prophylactic/therapeutic agent for various bone diseases (e.g., bone fractures).

Growing community of inventors

Osaka, Japan

Tetsuo Hoshino