Kyowa Hakko Kirin Co., Limited

Tetsuko Kazama

Rika Nagao

Nobuaki Eto

An objective of the present invention is to provide compounds that can effectively suppress the concentration of phosphorus in serum to effectively prevent or treat diseases induced by an increase in concentration of phosphate in serum. The compounds according to the present invention are compounds represented by formula (I) and pharmaceutically acceptable salts and solvates thereof: wherein A represents an optionally substituted five- to nine-membered unsaturated carbocyclic moiety or a five- to nine-membered unsaturated heterocyclic moiety, and&#x2003;represents a single bond or a double bond, Rrepresents optionally substituted aryl or the like, Z represents &#x2014;N&#x2550;CHRRor the like, Rand Rrepresent H, optionally substituted alkyl, optionally substituted aryl or the like, Rand Rtogether form &#x2550;O, and Rand Rrepresent H, or Rand Rtogether from a bond, and Rand Rtogether form a bond.

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Takasaki, Japan

Tetsuko Kazama