National Cerebral and Cardiovascular Center

Jms Co., Ltd.

Osaka University

Kowa Company Limited

Tokyo University of Science Foundation

Tetsuji Yamaoka

Atsushi Mahara

Sachiro Kakinoki

Mariko Shiba

Atsushi Yamashita

Takashi Yamamoto

Satoshi Obika

Tsuyoshi Yamamoto

Takeshi Imanishi

Yoshihito Kato

Yoshiya Hashimoto

Keisuke Narukawa

Hidetaka Torigoe

Shunsuke Baba

Yoichi Tachibana

Kiyomi Sasaki

Maria Chiara Munisso

Satoshi Kato

Atsushi Kasai

Tachibana Yoichi

Provided is a use for a peptide in surface-treating a medical device or medical material to be used in contact with blood, with which it is possible to obtain a medical device or medical material that can achieve highly efficient vascular endothelialization through the use of a peptide uniquely binding to vascular endothelial cells. Also provided are: a peptide suitable for use in said surface treatment; a method for producing a medical device or medical material surfaced-treated with said peptide and to be used in contact with blood; and a surface treatment agent including said peptide, said agent to be used in surface-treating a medical device or medical material to be used in contact with blood. In the present invention, a medical device or medical material is surface-treated using a peptide that includes any one of ten specific amino acid sequences and uniquely binds to the surface of endothelial progenitor cells.

Use for peptide uniquely binding to vascular endothelial cells, and peptide

A peptide that enables surface treatment of a scaffold for tissue repair that makes it possible to accelerate the repair of living tissue without using a material that negatively affects the repair of living tissue, a complex containing this peptide, a scaffold for tissue repair surface treated using this peptide or this complex, a surface treatment method for a scaffold for tissue repair using this peptide or this complex, and a treatment solution or set of treatment solutions to be used in this surface treatment method. Surface treatment of a scaffold for tissue repair is conducted by combining glycosaminoglycan and a peptide containing adhesive sites and basic sites each comprising predetermined amino acid residues.

Peptide and complex of same, scaffold for tissue repair and surface treatment method for same, and surface treatment solution or set of treatment solutions

In order to provide an artificial blood vessel that can prevent formation of a thrombus and a method for producing the artificial blood vessel, an artificial blood vessel is used (i) in which a peptide including a specific amino acid sequence has been added to an extracellular matrix obtained from a bio-derived vascular tissue and (ii) whose lumen has a cross sectional diameter of 4 mm or less.

Artificial blood vessel, and method for producing artificial blood vessel

An object of the present invention is to provide an oligonucleotide useful as a therapeutic agent for dyslipidemia that has excellent binding affinity to the PCSK9 gene as well as stability and safety. The oligonucleotide of the present invention contains a sugar-modified nucleoside, the sugar-modified nucleoside has a bridging structure between 4'-position and 2&#x2032;-position, and the oligonucleotide can bind to the human PCSK9 gene. Also, the present invention provides a therapeutic agent for dyslipidemia containing the oligonucleotide as an active ingredient, and the therapeutic agent preferably contains a bioabsorbable material as a carrier. The bioabsorbable material is preferably atelocollagen or peptide gel.

Oligonucleotide, and therapeutic agent for dyslipidemia containing oligonucleotide as active ingredient

A blood anticoagulant material is provided which has high expandability, reduced influence on living bodies, and can efficiently prevent blood coagulation. A multiblock copolymer having at least a structural unit represented by Formula (1), a structural unit represented by Formula (2), and a structural unit represented by Formula (3) is used: wherein, R, R, and Rin Formulas (1) to (3) each independently represent a divalent organic group, and m and n each independently represent an integer of 2 to 5000.

Blood anticoagulant material, coating material and indwelling device comprising the same, and treatment using blood anticoagulant material

To provide a drug for actively metabolizing or excreting a pathogen occurring in vivo. The present invention is directed to a compound which is formed of (A) an adsorbent for a pathogen occurring in the blood or lymph, and (B) a ligand which is specific to an organ or cells capable of metabolizing or excreting the pathogen and which is bonded to the adsorbent via a linker or with no linker, and to a drug containing the same.

Drug for suppressing pathogen occurring in vivo

Growing community of inventors

Osaka, Japan

Tetsuji Yamaoka