Daiichi Sankyo Company, Limited

Tetsuji Noguchi

Toshiyuki Konosu

Yuko Yamamoto

Yoshiko Kagoshima

Takuya Uchida

Hiroshi Takeshita

Tsuyoshi Soneda

Junichi Kuroyanagi

Tetsunori Fujisawa

Nobuhisa Masuda

Aki Yokomizo

Issei Achiwa

Takafumi Hosokawa

To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.

Imidazole carbonyl compound

An antibiotic compound having a novel mechanism of action, weak cytotoxicity, high solubility in water, effective in inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and having antibacterial activity.

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Tokyo, Japan

Tetsuji Noguchi