Omron Corporation

Tetsuichi Wazawa

Shigeru Aoyama

Takeo Nishikawa

Tomohiko Matsushita

Shigemi Norioka

Yuko Tsuda

Shingo Nagaoka

The metal fine particlesare sparsely fixed on the surface of the transparent substrate, and the acceptorfor attaching the specific ligand is immobilized on the transparent substrateor the metal fine particles. The prismis closely attached to the lower surface of the transparent substrate, and the excitation light enters the transparent substratethrough the prism. The incident light is totally reflected at the surface of the transparent substrate, and the evanescent light generated at the surface and the metal fine particleslocally plasmon resonate. As the evanescent light and the metal fine particles locally plasmon resonate, a strong electric field is enclosed in the vicinity of the metal fine particles. When the surface arranged with the metal fine particlesand the acceptoris contacted to the analysis sample solution containing ligand modified with light emitting molecules, only the light emitting molecule modifying a specific ligand attached to the acceptor emits light.

Localized plasmon resonance sensor and examining device

A method of mass-producing minute structures such as biochips, protein chips, quantum dots, and quantum chips involves arranging an antigen two-dimensionally on a board and arranging probes two-dimensionally facing the same direction so that the binding sites of the probes may bind to the antigen. An inorganic substance such as Ni is deposited on the board from the upper side of the probes by sputtering or evaporation to form a thin film layer and on the top surface of the flatly formed thin film layer, a supporting layer is formed by separating out the same inorganic substance using electrotyping. Then, by peeling the thin film layer and the supporting layer off of the board together, the mother stamper having cavities for the patterns of biomolecules is obtained.

Method of transcribing biomolecular patterns, method of manufacturing chip boards, and method of manufacturing biochips

At both ends of a waveguidehaving a plurality of cores, light emitting elementsand light receiving elementsare disposed so as to face end faces of the cores. A switchis overlapped over the waveguide. In the switch, switching windowseach can be switched between a state where light propagating through the coreis passed and a state where the light is reflected are arranged in the vertical and horizontal directions, and the switching windowsare arranged along the top faces of the cores. A test boardhaving a plurality of channelsin each of which a metallic thin filmis formed is disposed over the switch, and receptorsare fixed on the metallic thin filmin the channels. A specimen containing a specific ligand is passed in each of the channels

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Sendai, Japan

Tetsuichi Wazawa