Dainippon Sumitomo Pharma Co., Ltd.

Other

Tetsuhiro Ogino

Ayumu Kurimoto

Yoshiaki Isobe

Haruhisa Ogita

Haruo Takaku

Masanori Tobe

Hajime Kawakami

Hitoshi Fujita

A drug for topically administration which is effective as an antiallergic agent. The drug for topically administration contains as an active ingredient an adenine compound represented by the general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; Xrepresents oxygen, sulfur, NR(Rrepresents hydrogen or alkyl), or a single bond; Yrepresents a single bond, alkylene, etc.; Yrepresents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Qand Qrepresents &#x2014;COOR(wherein Rrepresents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

Adenine compound and use thereof

This invention relates to an adenine derivative, a tautomer thereof, or a pharmaceutically acceptable salt thereof represented by general formula (I): wherein X represents NR(wherein Rrepresents a hydrogen atom or Calkyl) or the like; Rrepresents substituted or unsubstituted alkyl or the like; Rrepresents hydroxyl or the like; and Y represents a substituted or unsubstituted aromatic hetero ring or the like. Also, the present invention relates to pharmaceuticals such as an interferon inducer, antiviral agent, anticancer agent, type 2 helper T cell selective immune response inhibitor, antiallergic agent, and immune response modulator comprising the above derivative as an active ingredient.

Adenine derivatives

The present invention relates to a heterocyclic compound of the following general formula (I):

Heterocyclic compounds

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Osaka, Japan

Tetsuhiro Ogino