Chugai Seiyaku Kabushiki Kaisha

Tetsuhiro Mikami

Satoshi Watanabe

Masahiro Kato

Makoto Uehara

Hiroyoshi Watanabe

Kiyoshige Ochi

Noboru Kubodera

Kaname Tsuzaki

Masahiro Katoh

Koji Oikawa

Tadao Michishita

A process for preparing a vitamin D derivative including providing an ultraviolet irradiation apparatus for photochemical reactions, which has an ultraviolet radiation-emitting lamp, an optical system which receives light from the ultraviolet radiation-emitting lamp and emits ultraviolet rays having a specific wavelength, and a quartz rod which receives the ultraviolet rays having the specific wavelength from the optical system and emits the ultraviolet rays, irradiating a solution of a provitamin D derivative with the ultraviolet rays emitted from the quartz rod to cause a photochemical reaction to the provitamin D derivative solution, thereby forming a previtamin D derivative, and subjecting the previtamin D derivative to a thermal isomerization reaction to prepare the vitamin D derivative.

Ultraviolet irradiation apparatus for photochemical reaction and preparation process of vitamin D derivative making use of the same

Highly crystalline 22-oxavitamin D derivatives

22-oxacholecalciferol derivative and process for preparing the same

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Tokyo, Japan

Tetsuhiro Mikami