Mitsubishi Tanabe Pharma Corporation

Tetsu Nakane

Akira Kubo

Ritsuo Imashiro

Hidetaka Miyoshi

Akihito Ogasawara

Tatsuo Nakajima

Hajime Hiramatsu

Hiroaki Sakurai

Atsushi Sato

Yasuo Yamamoto

Hidekazu Tsujishima

Kouichi Tanimoto

Chihiro Toshikawa

Takanori Murakami

The present invention relates to a novel imidazole compound or a pharmaceutically acceptable salt thereof having a melanocortin receptor agonistic activity, and medical use thereof. The present invention relates to an imidazole compound represented by general formula [I] [wherein: Ring A represents an optionally substituted aryl group or the like; Rrepresents a hydrogen atom, an optionally substituted alkyl group, or the like; Rrepresents a hydrogen atom, a halogen atom, or the like; and Rrepresents an optionally substituted alkyl group] or a pharmaceutically acceptable salt thereof.

Substituted imidazoles as melanocortin receptor agonists

The present invention relates to a compound of the formula [I]: wherein Gis an alkyl which is substituted by a halogen atom or an alkoxy, or a group of the formula: wherein ring B is benzene ring which may be substituted, etc., Q1 and Q2 may be the same or different, and each is hydrogen atom, a halogen atom or an alkyl, n is 0, 1, 2, 3 or 4, Ris hydrogen atom, an alkyl which may be substituted, a cycloalkyl which may be substituted, a phenyl which may be substituted, etc., Z, Z, Zand Zmay be the same or different, and each is CH or N, provided that 3 or more of Z, Z, Zand Zshould not be N at the same time, Gis hydrogen atom, &#x2014;NRR, &#x2014;OR, etc., where Rto Reach is independently hydrogen atom, an alkyl which may be substituted, an alkenyl, an alkynyl, etc., or a pharmaceutically acceptable salt thereof.

4-imidazolin-2-one compounds

The present invention is to provide a novel heterocyclic compound of the formula [I]: 

Heterocyclic compound which may be used as a medicine having p38 MAP kinase inhibitory activity

The present invention relates to a compound of the formula [I]:  

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Osaka, Japan

Tetsu Nakane