Medtronic, Inc.

Medtronic Vascular, Inc.

Arteriocyte Medical Systems, Inc.

Tessy Kanayinkal

Trevor Huang

Charlene X Yuan

Mark T Stewart

Paul T Rothstein

David E Francischelli

Roderick E Briscoe

Douglas H Gubbin

Tom P Daigle

Michael J Hobday

Daniel Cheek

Daniel Charles Haeg

David J Kim

Patrick Cloutier

Christopher Plott

Craig D Petersen

Andrew Olson

Lawrence Erickson

Joseph E Cardinal

Jessica L Foley

Christopher W Smith

Leonard H Leuer

James R Keogh

Dennis L Brooks

Kevin D McIntosh

Jack Chu

Thomas Daigle

Brian J Steffens

Christopher J Plott

Scott Doig

Kenneth E Merte

Erick L Johnson

Asha S Nayak

Rohit Cariappa

Debra Mullins-Hirte

Laura A Yonce

Charlene Yuan

Patrick J Cloutier

Daniel C Haeg

David JS Kim

Andrew L Olson

A method carried out by a system configured to analyze platelet aggregation includes retaining a ferromagnetic object at an elevation of a chamber in which a sample of blood or plasma is disposed. The ferromagnetic object is retained at the elevation for a period of time. The ferromagnetic object is then released from the elevation. The ferromagnetic object minimal position is measured following the release of the ferromagnetic object. The object minimal position may be correlated with amount of platelet aggregation in the sample.

Apparatus and method for analyzing platelet aggregation

A method carried out by a system configured to analyze blood. The method includes causing a ferromagnetic object to move in a chamber housing blood after clot initiation has been implicated. Movement of the object in the chamber is detected. The detected movement of the object is correlated with clot retraction of the blood. In some embodiments, the stop of detecting movement includes allowing the object to drop from a raised position and detecting a drop distance of the object. In related embodiments, the step of correlating detected movement with clot retraction includes reviewing a trace generated by a plurality of drop distances over time. In yet other embodiments, methods of the present disclosure can further including evaluating platelet function of the blood based upon assessed clot retraction.

Systems and methods for assessing blood platelet function

Systems and methods to analyze blood or other fluid sample. The systems and methods utilize bi-directional magnetic forces to push or pull a magnetic object along a post in a chamber housing the fluid sample both before and after clot initiation has been implicated. The magnetic object can be threadably connected to the post. In other embodiments, the chamber is configured such that the magnetic object does not rotate but only slides along the post. Once a clot has been detected, the washer can be moved either up or down to apply either compressive force or strain within the clot, as desired, to evaluate elastic properties or firmness of the clot.

Systems and methods for controlling bi-directional forces for clot assessment

Activated clotting time (ACT) tests detect blood clotting time based on the viscosity changes of a test sample, using a ferromagnetic washer lifted to the top of a test chamber and then dropped from the top via gravity; a drop time greater than a preset threshold value indicates clotting of the test sample. Blood samples which have high levels of heparin usually produce very weak clots that may easily be destroyed by the lifting movement of the washer. But if the clot threshold is set low to detect the weak clots, false detections occur during early testing cycles when activators are not fully suspended during the mixing cycle. Improved algorithms for lifting the washer and adjusting over time enable accurate detection of weak clots.

Clot protection and detection algorithm for activated clotting time testing

Multi-zone falling washer blood clot detection

The present invention provides biological compositions and methods for making the same.

Compositions and methods of preparation thereof

Methods for ameliorating stent graft migration and endoleak using treatment site-specific cell growth promoting compositions in combination with stent grafts are disclosed. Also disclosed are application of cell growth promoting compositions such as, but not limited to, autologous platelet gel compositions directly to treatment sites during or after stent graft implantation.

Systems and methods to reduce gel retraction

A novel occluder application and clip device for treatment of embolic stroke caused by atrial fibrillation uses multiple sutures in a non directional handle to affix the occlusion device to the applicator and manipulate the occluder from an open and receiving position to a closed and occluding position. The occluder is retained in place by a clamping means related to locks retainers, resilient material or otherwise. An actuator mechanism is used to manipulate the occluder to a locked or occluding position. The applicator with the occluder attached has a low profile and remote manipulations to allow the occluder to be delivered to the clamping location within a patient through a small incision or delivery port such as a trocar cannula or the like.

Methods and devices for occlusion of an atrial appendage

The invention provides a system for occluding a left atrial appendage of a patient. The system can include a ring occluder that can be positioned around the left atrial appendage and a ring applicator to position the ring occluder with respect to the left atrial appendage. The system can also provide a tissue-grasping tool that is separable from the ring applicator tool.

Device for occlusion of a left atrial appendage

Growing community of inventors

Brooklyn Park, MN, United States of America

Tessy Kanayinkal