Optimer Pharmaceuticals, Inc.

Tessie Mary Che

Youe-Kong Shue

Yu-Hung Chiu

Alex Romero

Yoshi Ichikawa

The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to(''),(''),species, for example, methicillin-resistant, orincluding Vancomycin-resistant enterococci.

Macrolide polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due to(''),(''),species, for example, methicillin-resistant, orincluding Vancomycin-resistant

Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Macrocyclic polymorphs, compositions comprising such polymorphs and methods of use and manufacture thereof

Polymorphic crystalline forms of tiacumicin B

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San Diego, CA, United States of America

Tessie Mary Che