Merck Sharp + Dohme Corp.

Photosonix Medical, Inc.

Tessie Brown McNeely

Mark Evan Schafer

Leslie Cope

Amita Joshi

Donna Lorraine Montgomery

Mark Andrew Miller

Hongxia Fan

Annaliesa Sybil Anderson

Loren D Schultz

William L McClements

Rosemarie Kelly

Arthur Fridman

James C Cook, Iii

Sharon Smith

Gregory D Pancari

Irene Pak

Gregory P Pancari

Mark D Yeager

A portion of a treatment device for treating bacteria may be coupled with the bacteria through direct or indirect contact. Mechanical stress energy and electromagnetic energy are generated with the treatment device, and are transmitted from the treatment device to the bacteria during the coupling. The bacteria are treated with both the mechanical stress energy and the electromagnetic energy to produce a killing effect on the bacteria. A treatment device may include a mechanical stress energy emitting portion, an electromagnetic energy emitting portion, and a contacting portion for coupling into direct or indirect contact with the bacteria and transmitting mechanical stress energy to the bacteria during the coupling. The mechanical stress energy emitting portion and the electromagnetic energy emitting portion are operable to treat the bacteria with a combination of mechanical stress energy and electromagnetic energy to produce a killing effect on the bacteria.

Methods, devices, and systems for treating bacteria with mechanical stress energy and electromagnetic energy

The present invention relates to methods of inducing an immune response tocomprising administering a composition comprising an SA2451-related polypeptide fromas well as derivatives or fragments thereof. The present invention also encompasses methods of treating and/or reducing the likelihood of ainfection by administering a composition comprising an SA2451-related polypeptide or an antibody that specifically binds to an SA2451 polypeptide, derivative or fragments thereof. Compositions administered in the methods of the invention can include one or more additional antigens. Compositions used to practice the methods of the invention are also encompassed.

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The present invention relates to peptides of the enolase protein fromas well as nucleic acid and nucleic acid sequence homologs encoding the peptides. The present invention also relates to a composition, particularly avaccine, comprising one or more of the enolase peptides described herein or a fragment, derivative or variant thereof capable of generating an immune response that induces a protective antibody response or opsonophagocytic activity of human neutrophils for. The present invention also encompasses methods of treating and/or reducing the likelihood of ainfection by administering a composition of the invention.

The present invention relates to methods of inducing an immune response tocomprising administering a composition comprising an SA2493-related polypeptide fromas well as derivatives or fragments thereof. The present invention also encompasses methods of treating and/or reducing the likelihood of ainfection by administering a composition comprising an SA2493-related polypeptide or an antibody that specifically binds to an SA2493 polypeptide, derivative or fragments thereof. Compositions administered in the methods of the invention can include one or more additional antigens including, but not limited to, IsdB. Compositions used to practice the methods of the invention are also encompassed.

The novel protein SA1789 fromis provided as well as nucleic acid and nucleic acid sequence homologues encoding this protein. Also provided is a composition, particularly avaccine, comprising SA1789 protein or a fragment or derivative thereof capable of generating an immune response that leads to the killing and clearance of

The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 and uses of such polypeptides. SEQ ID NO: 1 is a truncated derivative of a full-lengthpolypeptide. The full-length naturally occurring polypeptide is referred to herein as full-length ORF1319e. A His-tagged derivative of SEQ ID NO: 1 was found to produce a protective immune response against

The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof,AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full lengthAhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against. 

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Gwynedd Valley, PA, United States of America

Tessie Brown McNeely