University of Massachusetts

Tessa Mercedes Simone

Guangping Gao

Michael R Green

Miguel Sena Esteves

Dan Wang

In some aspects, the disclosure relates to compositions and methods of engineering a transgene. In some embodiments, the disclosure provides self-regulating recombinant nucleic acids, viral vectors and pharmaceutical compositions comprising a MeCP2 transgene. In some embodiments, compositions and methods described by the disclosure are useful for treating diseases and disorders associated with a loss of function mutation, for example Rett syndrome.

Growing community of inventors

Worcester, MA, United States of America

Tessa Mercedes Simone