Canon Kabushiki Kaisha

Teruyuki Kondo

Tetsuya Yano

Hidetoshi Tsuzuki

Atsushi Takahashi

Tetsuya Matsuda

Hidehito Tochio

Yoshinori Tomida

Kimihiro Yoshimura

Satoshi Ogawa

Masato Minami

Fumio Yamauchi

Katsuaki Kuge

Shinsuke Sando

Hiroki Miura

Yasuhiro Aoyama

Hisatsugu Yamada

Yoshinori Hasegawa

Hiroshi Tsujita

Zainul Abedin Siddique

Yu Kimura

Shingo Matsuki

Michiko Narazaki

Kengo Kanazaki

Masahiro Shirakawa

Fuminori Sugihara

Natsuki Matsumoto

To provide a polymer having a high ratio of the amount thereof present in a tumor to the amount thereof present in blood (hereinafter, sometimes abbreviated as a tumor/blood ratio). The polymer has phosphorylcholine (derivative) as a side chain and has a dye (near-infrared dye) having absorption in the near-infrared wavelength region bound to the polymer.

Polymer and contrast agent for photoacoustic imaging including the polymer

As a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging, a substance with high selectivity and high sensitivity was demanded. According to the present invention, when a polymer having, in a side chain thereof, a sequence of aH&#x2014;C&#x2014;N,H&#x2014;N&#x2014;C orH&#x2014;C&#x2014;C bond, that is, a structure labeled with stable isotopes ofC andN, is used, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.

Polymer, contrast agent for nuclear magnetic resonance analysis or magnetic resonance imaging using the polymer, compound and method of nuclear magnetic resonance analysis and method of magnetic resonance imaging using the polymer

A core of a cyclic structure represented by (&#x2014;N&#x2014;(CH)&#x2014;)is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.

Aza metal complexes

AZA compounds and production method thereof, and metal complexes as MRI contrast agents

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Kyoto, Japan

Teruyuki Kondo