Nipro Corporation

Japan Science and Technology Agency

Nippon Oil Fats Co., Ltd.

Yoshitomi Pharmaceutical Industries, Ltd.

Teruyuki Komatsu

Eishun Tsuchida

Hiroyuki Nishide

Shinji Takeoka

Toshiya Kai

Naohisa Katayama

Makoto Sato

Akito Nakagawa

Naomi Ohmichi

Etsuo Hasegawa

Hiromi Sakai

Yoshinori Kida

Ippei Fukutomi

Junichi Yokoe

Yuko Azuma

Ippei Hukutomi

Keitaro So

Yasuko Matsukawa

A porphyrin compound represented by general formula (A): Also disclosed are a porphyrin metal complex-albumin inclusion compound having a porphyrin compound, in which M denotes Fe or Co, included in albumin, and an artificial oxygen carrier containing the porphyrin metal complex-albumin inclusion compound as an active component.

Porphyrin compound, albumin inclusion compound thereof and artificial oxygen carrier

A pharmaceutical composition containing an artificial oxygen carrier, which has high oxygen carrying efficiency; and has a required colloid osmotic pressure, an appropriate crystalloid osmotic pressure, pH, and electrolyte balance. The composition is prepared by appropriately adding at least one substance selected from the group consisting of a compound capable of providing a colloid osmotic pressure, an electrolyte, a saccharide, an amino acid, an antioxidant, a pH adjuster, and an isotonizing agent to a preparation including a liposome-encapsulated hemoglobin in which a hemoglobin is encapsulated in a liposome or to a preparation including a conjugate of a porphyrin-iron complex and albumin.

Pharmaceutical composition containing artificial oxygen carrier

The present invention provides a method of producing a complex of albumin and a deoxy form metal complex having a porphyrin structure, which includes mixing albumin and a metal complex having a porphyrin structure under a gas atmosphere substantially free of carbon monoxide and oxygen, as a method of producing an artificial oxygen carrier containing a complex of albumin and a metal complex having a porphyrin structure, under a deoxidation (nitrogen, other inert gases) atmosphere without using carbon monoxide.

Artificial oxygen carrier and production method thereof

A porphyrin metal complex that can form a stable oxygen complex and acts effectively as an oxygen infusion, which comprises: 

Porphyrin-metal complexes and oxygen infusions containing the same

A porphyrin metal complex-albumin inclusion compound wherein a substituted porphyrin metal complex comprising, as a central, coordinated metal, a transitional metal belonging to the fourth or fifth period of the periodic law, is included in the albumin, and an oxygen carrier composition comprising said inclusion compound as an active ingredient. The compound functions as an oxygen carrier which is superior in biocompatibility, capable of adsorption and desorption of oxygen under physiological conditions, and is rather easily produced at an industrial scale.

Porphyrin metal complex-albumin inclusion compound and oxygen carrier

5,10,15,20-tetra(2',6'-dipivaloyloxyphenyl)porphinato metal complex

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Tachikawa, Japan

Teruyuki Komatsu