Kagoshima University

Sumitomo Bakelite Company Limited

Jnc Corporation

Teruto Hashiguchi

Masao Fukushima

Hiroki Abe

Hideyuki Shimaoka

Ikuro Maruyama

Midori Abe

Salunya Tancharoen

Taichi Aihara

Kota Igarashi

Masaru Sekijima

Norichika Moriwaki

Yuko Mataki

Kosei Maemura

Hiroyuki Shinchi

Yasuto Uchikado

Shoji Natsugoe

Lyang-ja Lee

Kenji Tanaka

Ko-ichi Kawahara

Ko-Ichi Kawahara

Lyang-Ja Lee

The present invention provides an inhibitor of an autoimmune response to a periodontal bacterial enzymatic degradation product of keratin in gingival epithelium in a mammal having a periodontal bacterium in the oral cavity, containing a substance having affinity to the keratin or a degradation product thereof and/or a substance having affinity to an autoantibody to the degradation product, an agent for the prophylaxis and/or treatment of a periodontal disease and/or a complication thereof; a RANKL expression inhibitor containing a substance having affinity to the keratin or a degradation product thereof; and a method of diagnosing a periodontal disease including detecting the keratin or a degradation product thereof and/or an autoantibody thereto.

Periodontal-disease-specific peptide, and treatment and diagnosis of periodontal disease using same

As a result of collecting blood from pancreatic cancer patients, esophageal cancer patients, and stomach cancer patients, and conducting mass spectrometry on N-linked sugar chains in the plasmas, sugar chains whose abundances are significantly different from those of healthy subjects have been successfully identified from the blood samples of the cancer patients.

Method for inspecting gastroenterological cancer by utilizing N-linked sugar chain

Growing community of inventors

Kagoshima, Japan

Teruto Hashiguchi