Kabushiki Kaisha Yakult Honsha

Daiichi Pharmaceutical Co., Ltd.

Teikoku Hormone Mfg. Co., Ltd.

Teruo Yokokura

Shusuke Hashimoto

Takeshi Matsuzaki

Tadashi Miyasaka

Seigo Sawada

Takashi Yaegashi

Ryuta Yamazaki

Masato Nagaoka

Tsunekazu Watanabe

Yoshiyuki Shishido

Seizaburo Kobayashi

Masahiko Mutai

Masashi Sakai

Kenichi Tezuka

Hiroshi Nagata

Kenichiro Nokata

Koji Nomoto

Ritsuo Aiyama

Haruji Sawada

Tomoyuki Sako

Kunio Kado

Satoru Okajima

Ikuo Kato

Tomio Furuta

Tunekazu Watanabe

Masaaki Watanuki

Kisaku Shimura

Tsuneo Matsumoto

Osamu Matsuo

Hiroshi Sansawa

Masaharu Onoue

Masayoshi Furushiro

Shuichi Tanabe

Tetsuya Terasaki

Kouichi Hirai

Masayoshi Furusiro

Mahoko Motoike

Peptides and nootropic agent

Specific cyclooxygenase 2 inhibitor and anti-inflammatory agent

New camptothecin derivatives of the general formula (1): ##STR1## wherein R.sup.1 represents a hydrogen atom or a C.sub.1 -C.sub.6 alkyl group, R.sup.2 represents a hydrogen or a C.sub.1 -C.sub.6 alkoxy group, R.sup.3 represents a hydrogen or halogen atom or a C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, hydroxyl, C.sub.2 -C.sub.6 acyloxy or methoxyethoxymethoxy group, R.sup.4 represents a hydrogen or halogen atom, and R.sup.5 represents a C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 unsaturated alkyl, alkylthioalkyl, alkoxyalkyl, pyridyl or substituted phenyl group, with the proviso that all of the R.sup.2, R.sup.3 and R.sup.4 substituents should not be a hydrogen atom, and a process for preparing the new camptothecin derivatives by subjecting the camptothecin derivatives of the general formula (2): ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the same meanings as given above, to the reaction with N,N-dimethylethylenediamine without solvent to open the E-lactone ring followed by acylation of 17-hydroxyl group with corresponding acylating agents and an antitumor agent containing the same as an active ingredient.

Camptothecin derivatives, preparations thereof and antitumor agents

A diarylheptanoide derivative of the following formula (1), ##STR1## and a drug composition comprising this compound, such as a 5-lipoxygenase inhibitor, an antiinflammatory agent, and the like. The diarylheptanoide derivative (1) is effective for treating and preventing various inflammatory diseases due to its strong 5-lipoxygenase inhibiting effect.

Diarylheptanoide derivative and pharmaceutical composition comprising

An antiulcer agent effective on prevention of ulceration and acceleration of healing of ulcers and processes for preparing the same are disclosed. The antiulcer agent comprises rhamnan (a homopolysaccharide), rhamnose or a rhamnose oligomer as an active ingredient. Rhamnan is prepared by separating rhamnan sulfate from rhamnan sulfate-containing algae and desulfurating the rhamnan sulfate. Rhamnan oligomers are prepared by hydrolyzing rhamnan obtained by desulfuration of rhamnan sulfate or by hydrolyzing microbial cells of a Bifidobacterium or polysaccharides separated therefrom.

Antiulcer agent and process for preparing the same

An antitumor agent is provided by including, as an active ingredient, a polysaccharide-glycan complex obtained by treating a Gram-positive bacteria such as lactic acid bacteria and Bifidobacterium strains with a cell wall lytic enzyme produced by a bacterium belonging to the genus Achromobacter. The polysaccharide-glycan complex has no toxicity and causes no side effect. Being water-soluble, it is easily formulated into any arbitrary dose form, such as an injectable solution. It can easily be prepared from an easily available starting material.

Antitumor polysaccharide-glycan complexes

Thrombolytic peptide, production thereof, and thrombolytic agent

The present invention relates to antihypertensives and food and drinks, containing as effective component polysaccharideglycopeptide complexes derived from cell wall of Gram positive bacteria (also referred to as peptidoglycan). The present invention provides extremely strong and safe antihypertensives and food and drinks, which may exert hypotensive effects if administered orally to spontaneous hypertensive rats and renal hypertensive rats at a single dose as low as 1 mg/kg.

Antihypertensives containing polysaccharide peptidoglycan complexes

New campotothecin derivatives and a process for preparing same are disclosed, which are represented by the general formula: ##STR1## wherein R.sup.1 represents a lower alkyl group, R.sup.2 represents a hydrogen atom or an amino, hydroxyl, lower acylamino or lower alkoxy group, R.sup.3 represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, nitro, amino, cyano or di(lower alkyl)amino group, R.sup.4 represents a hydrogen or halogen atom or a lower alkyl, hydroxyl, lower alkoxy, lower alkylthio, amino, cyano or di(lower alkyl)amino group, and R.sup.5 represents a hydrogen or halogen atom or a hydroxyl or lower alkoxy group, with the proviso that all of the R.sup.2, R.sup.3, R.sup.4 and R.sup.5 substituents should not be a hydrogen atom and also that if any one of the R.sup.2, R.sup.3, R.sup.4 and R.sup.5 is a hydroxyl or lower alkoxy group, all of the other three substituents should not be a hydrogen atom.

Camptothecin derivatives

Immunostimulating agent for inhibiting tumors comprising Lactobacillus casei YIT 9018 and methods for treating and/or preventing tumor growth.

Antitumor agent containing Lactobacillus casei YIT 9018

Growing community of inventors

Tokyo, Japan

Teruo Yokokura