Shionogi Company Limited

Teruo Sakamoto

Toyohiko Takeda

Yusuke Suzuki

Yoshio Hamashima

Kyozo Kawata

Kyoji Minami

Kinzaburo Noda

Masanori Tujikawa

Sadao Kawai

Toshiro Fujii

Toshihiro Ogura

Hayao Inoue

Hiroshi Kato

Fumio Sato

Seiichi Watashiro

Yoshihito Yahata

Sustained-release preparations essentially consisting of 1 part by weight of a water-soluble active ingredient and 1 to 10 parts by weight of two or more fats where the melting point is different in one from others, being capable of releasing active ingredients at a constant rate for a long-period of time, and being manufactured easily and economically.

Sustained-release preparations and the process thereof

An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule and sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.

Gelatin hard capsule containing crystalline hydrate of oral cephalosporin

Method for preparing crystalline hydrate of oral celphalosporin and its

Sustained-release formulations which can release a water-soluble active ingredient or ingredients at the zero-order over a long period of time, comprising:

Sustained-release formulation and production thereof

An antibacterial, 7.beta.-[(Z)-2-(2-aminothiazol-4-yl)-4-carboxybut-2-enoylamino]-3-cephem-4 -carboxylic acid is stable in a (di or tri)-hydrate crystal form. A pharmacologically effective amount of this hydrate is filled in a gelatin hard capsule sealed by a band of gelatin to make a stable composition for clinical use after storage for a long time.

Crystalline hydrate of oral cephalosporin and its composition

Highly effective and orally administrable sustained-release preparation of an antihypertensive agent, pinacidil (N'-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) comprising a rapid-release and a slow-release component at a ratio of about 7:3 to about 1:9 by pinacidil weight.

Sustained-release preparation of pinacidil

Highly potent long-acting formulation of cefaclor for treating bacterial infections in human or animals, comprising a rapid-release and a slow-release component at a ratio of about 3:7 to about 5:5 by potency of cefaclor, convenient for administration or carrying about.

Long-acting formulation of cefaclor

A composite measure of varying capacity, composed of supplying-aperture of straight cylinder and an inside measure telescopically inserted into the aperture and having a hollow of frusto-conical section, is employed in order to improve accommodation of the known conventional capacity type rotary powder filling machine, to powder of varying bulk density. A turntable which receives the supplying-aperture, superimposes over another turntable which holds the inside measure, and the distance between the both, is adjustable during the operation in accordance with the variance in the bulk density. The height of the container transferring path is also adjustable simultaneously with that of the second turntable. Spouting of compressed-air through an annular nozzle the diameter of which approximates to that of the aperture as a flow parallel to their inside wall is effected to blow off remaining powder in the measure and clean the same when the nozzle is disposed on the aperture. Evacuation for removing air from an empty or partly filled container is made through an annular suction inlet capable of suctioning the air as a flow parallel to the inside wall of the container.

Growing community of inventors

Osaka, Japan

Teruo Sakamoto