Other

Santen Pharmaceutical Co., Ltd.

Nihon Tenganyaku Kenkyusho Co., Ltd.

Nishida, Teruo

Teruo Nishida

Masatsugu Nakamura

Makoto Inui

Katsuhiko Nakata

Yorihisa Uetake

Hiroaki Iwata

M Nakamura

Masatsugu Santen Pharmaceutical Co Ltd Nakamura

Katsuhiko Santen Pharmaceutical Co Ltd Nakata

Y Nihon Tenganyaku Kenkyusho Co Ltd Uetake

An object is to find the minimum activity expression site of fibronectin, clarify the actions of this minimum unit in relation to opthalmological fields, and provide an opthalmological composition having this minimum unit as an effective component. This invention provides an opthalmological composition, in particular, a corneal disorder treatment agent containing the peptide, PHSRN (SEQ ID NO: 1) (Pro-His-Ser-Arg-Asn (SEQ ID NO: 1)), or Ac-Pro-His-Ser-Arg-Asn-NH, which is a derivative thereof, or a salt thereof that is allowable as a medical drug as an effective component. The preferred dosage form is an ophthalmic formulation.

Ophthalmological composition

A therapeutic method for treating a skin wound involving administering to a patient in need thereof a composition containing pharmaceutically effective amounts of the following components: (1) a peptide consisting of the amino acid sequence represented by Ser-Ser-Ser-Arg (SEQ ID NO: 1) or pharmaceutically acceptable salts thereof and (2) a peptide consisting of the amino acid sequence represented by Phe-Gly-Leu-Met-NH(SEQ ID NO: 2) or substance P or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable additive.

Methods for treating a skin wound

A method for treating a corneal disorder or for promoting skin wound healing comprising administering to a patient in need thereof a composition containing pharmaceutically effective amounts of (i) a first peptide comprising an amino acid sequence containing the following consecutive amino acids: Ser-Ser-Ser-Arg (SEQ ID NO: 1), or an analog thereof or a pharmaceutically acceptable salt thereof and (ii) a second peptide comprising an amino acid sequence containing the following consecutive amino acids with a terminal &#x2014;NHgroup: Phe-Gly-Leu-Met-NH(SEQ ID NO: 2), or an analog thereof or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier.

Methods for treating a corneal disorder and promoting skin wound healing

A peptide, wherein the peptide is selected from the group consisting of Ser-Ser-Ser-Arg (SEQ ID NO: 1),

Peptide containing Ser-Ser-Ser-Arg

The present invention provides healing promoters for skin wounds such as rupture, abrasion, surgical incision, skin ulcer and burn. Coexistence of Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH(SEQ ID NO:) or Phe-Gly-Leu-Met-NH(SEQ ID NO:) with insulin-like growth factor-I exhibits a remarkable promotive action on healing the skin wounds. Accordingly, combined administration of at least one of the substance P analogs and pharmaceutically acceptable salts thereof with the insulin-like growth factor exhibits a promotive effect on epidermal extension and a promotive effect on healing the skin wounds.

Skin wound healing promoters

An ophthalmic composition for treating corneal disorder which comprises Phe-Gly-Leu-Met-NH,or a pharmaceutically acceptable salt thereof as an active ingredient. Also a composition for treating corneal disorders, particularly a composition for promoting corneal epithelial migration, which comprises Phe-Gly-Leu-Met-NH,or a pharmaceutically acceptable salt thereof and an insulin-like growth factor I. Preferably the compositions are in the form of ophthalmic formulations.

Ophthalmic drug compositions

A method for the healing of wounds caused by corneal injury as the result of, for example, corneal ulcer, corneal epithelial defect, keratitis, xerophthalmia, which comprises locally administering to a patient in need thereof an effective wound healing amount of interleukin-6, either alone, or in combination with one or more pharmaceutically acceptable ophthalmic excipients.

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Ube-shi, Yamaguchi, Japan

Teruo Nishida