Fujirebio Kabushiki Kaisha

Teruo Kutsuma

Yoshiaki Sato

Hiroshi Ikawa

Tetsuaki Yamaura

Yoshikazu Isowa

Hajime Matsumoto

Yasuo Sekine

Akihiro Sekine

Noriaki Kashiwaba

Hisako Harada

Nobuhiro Hirakawa

Alkylamide derivatives having the formula, These compounds have a strong antiulcer action depend on histamine H.sub.2 -receptor antagonistic action and a cytoprotective action upon gastric mucous membrance.

Alkylamide derivatives with H.sub.2 -receptor antagonistic and

1,4-dihydropyridine derivatives represented by the following general formula, ##STR1## in which R.sup.3 is a combination of an unsaturated straight chain hydrocarbon group or derivative thereof connected by a single bond with an unsaturated hydrocarbon group or derivative thereof so that the unsaturated carbon atoms of the two groups are in conjugated relationship. These compounds have a hypotensive action the effective time of which is long, which makes the blood pressure descend slowly, and the toxicity of which is low.

Antihypertensive 1,4-dihydropyridines having a conjugated ester

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Tokyo, Japan

Teruo Kutsuma