Shionogi Company Limited

Teruo Hattori

Tadashi Yoshida

Koichi Matsumoto

Eiji Kondo

Jun'ichi Shoji

Junichi Shoji

Naoki Tsuji

Yoshimi Kawamura

Kentaro Tanaka

Kouichi Matsumoto

Takao Konishi

Yoshiyuki Hayashi

Yoshihiro Terui

This invention provides a novel compound of the formula: ##STR1## wherein X is L-HyPro or L-Pro, R is --CH.sub.3 or --CH(CH.sub.3).sub.2, and n is an integer from 9 to 12, or its salt, a process for producing the compound which comprises cultivating a microorganism which belongs to the genus Pseudomonas and produces the compound in a medium and recovering the compound from the medium and a biologically pure culture of Pseudomas sp. PB-6250 producing the compound.

Antibiotics plusbacin

A compound of the formula (I): ##STR1## wherein R is: (CH.sub.2).sub.8 CH.sub.3,

Antibiotics PB-6042S

An anti-mycoplasma agent comprising tropolone, its derivatives, represented by the formula: ##STR1## (wherein R.sub.1 is hydroxy, aliphatic acyloxy, arylacyloxy, arysulfonyloxy, carboxyalkyloxy or its ester, benzoylalkyloxy, alkenyloxy, 1,3-dihydro-3-oxo-1-isobenzofuranyloxy, (2-oxo-5-methyl-1,3-dioxol-4-yl)methyloxy or thiocyanato and R.sub.2 is hydrogen, halogen, hydroxy, alkyl or alkoxy) and their salts as an active ingredient, which has potent activity especially against tylosin-resistant mycoplasma both in vitro and in vivo and is effectively used in treating the diseases caused thereby.

Anti-mycoplasma agent

A new antibiotic having .beta.-lactamase inhibitory activity, PA-31088-IV, being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative phathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces tokunonensis sp. nov. in a suitable medium and recovering PA-31088-IV from the cultured broth.

Antibiotic PA-31088-IV and production thereof

Growing community of inventors

Hyogo, Japan

Teruo Hattori