Ss Pharmaceutical Co., Ltd.

Ssp Co. Ltd

Terumitsu Kaihoh

Susumu Sato

Hideaki Matsuda

Haruyoshi Honda

Fujiko Konno

Tomomi Okada

Hiroyuki Mizuno

Yoshinori Takahashi

Masago Ishikawa

Takemitsu Asaoka

Tadayuki Kuraishi

Sunao Takeda

Masaru Matsumoto

Akihiro Shibata

Fumio Ishii

Yoshihiro Nagao

Disclosed herein is a substituted piperidine derivative represented by the following general formula (1):

Substituted piperidine derivative for treating urinary disturbance

Disclosed are chromene derivatives represented by the following formula: ##STR1## wherein R.sup.1 s represent alkyl, alkoxy or like groups, R.sup.2 represents a hydrogen atom or an alkyl group, R.sup.3 represents a substituted or unsubstituted phenyl, naphthyl or heterocyclic group, and m stands for an integer of from 0 to 4, and their salts; and pharmaceuticals containing them as effective ingredients. The chromene derivatives and their salts show excellent AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.

Chromene derivatives and salts thereof, and pharmaceuticals containing

Described is an arylacetic amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents an aryl group or the like, R.sup.2 and R.sup.3 each independently represents an alkyl group, a cycloalkyl group or the like, and R.sup.4 represents an aralkyl group, an alkyl group or the like; or salt thereof. The compound according to the present invention has both excellent anticholinergic action and calcium antagonism and at the same time has high selectivity to bladder, so that it is useful as a preventive or remedy for urinary disorders.

Arylacetic amide derivative or salt thereof, and pharmaceutical

Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means an aryl or heteroaryl group which may have at least one substituent, R.sup.2 denotes an alkyl, alkenyl or aralkyl group, R.sup.3 stands for a hydrogen atom or an alkyl group, and R.sup.4 is a hydrogen atom, an alkyl group, or an aryl, heteroaryl, aralkyl, aralkenyl or heteroaralkyl group which may have at least one substituent, or a salt thereof. A medicine including this compound is also disclosed. The compound has excellent anticholinergic effect and calcium antagonism and inhibits reflex bladder contraction and is hence useful for prophylaxis of and treatment for a urinary disturbance such as pollakiuria.

Substituted piperidine derivative and medicine comprising the same

5-aminoquinolone carboxylic acid derivative and antibacterial agent

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Narita, Japan

Terumitsu Kaihoh