Shionogi Company Limited

Institute of Medicinal Molecular Design, Inc.

Terukazu Kato

Akihiro Hori

Koji Masuda

Akiko Itai

Manabu Katou

Naoki Yoshikawa

Susumu Muto

Shiro Kida

Eiichi Kojima

Yuuji Kooriyama

Tatsuhiko Ueno

Shuji Yonezawa

Chiaki Fujikoshi

Sae Matsumoto

Hiroshi Fukasawa

Takafumi Ohara

Mado Nakajima

Ryuko Tokuyama

Mitsuhiro Yonehara

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid &#x3b2; protein, for example, 

Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity

A compound represented by the formula: or its pharmaceutically acceptable salt. Ring A is aromatic carbocycle or aromatic heterocycle, Z is &#x2014;O&#x2014; or &#x2014;S&#x2014;, Ris hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like, Rand Rare each independently hydrogen, halogen, hydroxy or the like, Ris a group represented by the formula: &#x2014;(CRR)&#x2014;R, Rand Rare each independently hydrogen, halogen, hydroxy or the like, n is an integer of 0 to 3, Ris carboxy, cyano, substituted or unsubstituted alkyl or the like, Ris halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or the like, and m is an integer of 0 to 3.

Oxadiazole derivative having endothelial lipase inhibitory activity

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid &#x3b2; protein, for example, a compound represented by the formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group,Ris optionally substituted lower alkyl or the like,Rand Rare each independently hydrogen, optionally substituted lower alkyl or the like,Rand Rare each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like,or a pharmaceutically acceptable salt thereof, or a solvate thereof.

A compound of the formula (I): or a pharmaceutically acceptable salt thereof.

Derivative having PPAR agonistic activity

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Osaka, Japan

Terukazu Kato