Wakunaga Seiyaku Kabushiki Kaisha

Terukage Hirata

Satoshi Inoue

Masaharu Yokomoto

Nobuya Sakae

Koichi Tamura

Harunobu Amagase

Masanori Kakimoto

Kouji Nishimura

Yasushi Yoshimura

Hirotaka Amano

Masayasu Okuhira

Mitsuyasu Ushijima

Jun Nomiyama

Naoyuki Takasugi

Process for producing N-biphenylmethylthiadiazoline derivative or salt

Process for producing tetrazolylated biphenylmethane derivatives

This invention relates to a biphenylmethane derivative represented by the formula (1): ##STR1## wherein A represents a group ##STR2## in which R.sup.1, X, Y, Z and B are as defined in the Specification. The compounds have potent angiotensin II antagonist activity and anti-hypertensive effect. They have therapeutic utility for circulatory diseases such as hypertension, heart diseases and cerebral apoplexy.

Biphenylmethane derivatives and pharmaceuticals containing the same

The present invention provides dihydropyridine derivatives represented by the following formula (I) ##STR1## and salts thereof. They have extremely strong, slow and long-acting vasodilating action and antihypertensive action with less adverse effects so that they are useful as therapeutic agents for cardiovascular diseases.

Dihydropyridine derivative

Disclosed herein is a cerebral-circulation-metabolism-function-improving agent which contains a 2,6-diphenyl-3,7-dioxabicyclo[3.3.0]octane derivative represented by the following formula as the effective ingredient: ##STR1## wherein, each of R.sub.1, R.sub.3, R.sub.4 and R.sub.6 represents a hydrogen atom or a lower alkoxyl group; each of R.sub.2 and R.sub.5 represents a hydrogen atom, a .beta.-D-glucosyl group or a hydroxyl group; and each of R.sub.7 and R.sub.8 represents an oxygen atom or two hydrogen atoms.

Method for improving cerebral circulation

Growing community of inventors

Hiroshima, Japan

Terukage Hirata