Other

Kaken Pharmaceutical Company, Ltd.

Ensuiko Sugar Refining Co., Ltd.

Bio Research Corporation of Yokohama

Teruhiko Umetsu

Koji Hara

Kozo Hara

Katsuhiko Mikuni

Tadakatsu Mandai

Hiroshi Okumoto

Katsuyoshi Nakanishi

Kosho Nakamura

Yoshinori Tsuchiya

Taxoid derivatives and process for producing the same

Disclosed are ursodeoxycholic acid derivatives having an increased solubility in water, and methods for producing the derivatives. To produce the derivatives, ursodeoxycholic acid is protected at its carboxyl group with a benzyl group, then reacted with tetrabenzyl-acetic acid-oxyglucoside of the following formula (1), and de-benzylated; or ursodeoxycholic acid is protected at its hydroxyl group with a t-butyldimethylsilyl group, then reacted with tetrabenzyl-2-hydroxyethyloxyglucoside of the following formula (2), and de-t-butyldimethylsilylated and de-benzylated. ##STR1##

Ursodeoxycholic acid derivatives and methods for producing them

Growing community of inventors

Tokyo, Japan

Teruhiko Umetsu