Asahi Kasei Medical Co., Ltd.

Asahi Kasei Kogyo Kabushiki Kaisha

Asahi Medical Co., Ltd.

Asahi Kasei Kuraray Medical Co., Ltd.

Teruhiko Oishi

Naoki Morita

Keitaro Matsuyama

Morikazu Miura

Hiroshi Tajima

Toshinori Koizumi

Tatsuya Fukuda

Makoto Ozeki

Hiroshi Umeno

Yusuke Tokimizu

Tomoji Hanai

Hirofumi Miura

Hiroyoshi Ohya

Hitomi Araki

A closed circulation system test apparatus independently sets the amount of a liquid such as a dialysate for a blood purification device, facilitates management of operations of multiple pumps, and is capable of evaluating performance for removing wastes in blood and lifespan performance of membranes. The closed circulation system test apparatus includes: a blood sending line for sending blood from the blood bag to the blood purification device via a blood pump; a blood returning line for sending blood exiting from the blood purification device to the blood bag via a resistance imparting means; a filtrate line for sending the filtrate exiting from a dialysate outlet of the blood purification device to the replacement fluid container via a filtrate pump; and a dialysate line for sending, via a dialysate pump, dialysate or replacement fluid from the replacement fluid container to a dialysate inlet of the blood purification device.

Closed circulation system test apparatus for blood purification device using whole blood

A blood purifier includes a porous molded body; exhibits an excellent blood compatibility wherein platelet adherence is inhibited and exhibits a good cytokine adsorption capacity and a low pressure loss before and after blood treatment; and can be safely used. A blood purifier includes a main vessel and a porous molded body housed in the main vessel. The porous molded body contains a hydrophobic polymer and a hydrophilic polymer. The amount of low-melting-point water per 1 g of dry weight of the porous molded body is 0.12 g to 2.00 g. The contact change ratio for the porous molded body is 0% to 0.2%. The ratio L/D is 1.00 to 2.30 where, for the region taken up by the porous molded body in the main vessel, L is the length in the flow direction and D is the circle-equivalent diameter of the cross section in the direction perpendicular to the flow direction.

Blood purifier

A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: the concentrations of Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Rb, Sr, Y, Zr, Mo, Ru, Ag, Cd, Sn, Cs, La, Pr, Sm, Gd, Tb, Ta, Au, Tl, Co, In, and Bi are each 0.1 ppb or less and the concentrations of Ba, Nd, Pb, And Ce are each 1 ppb or less in a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device; and the number of fine particles having a size of 10 μm or more is 25 or less and the number of fine particles having a size of 25 μm or more is 3 or less in 1 mL of the physiological saline solution for injection.

Blood purification device and method for producing same

Provided is a blood purification device including a porous molded body that has a high phosphorus adsorption capacity and that can be used safely. A blood purification device includes a porous molded body containing an inorganic ion-adsorbing material and is characterized by the following: said blood purification device satisfies the relationship B=&#x2212;0.02 A+2.175&#xb1;0.185 (74&#x2264;A&#x2264;94) when the moisture content of the porous molded body is denoted by A and the bulk density is denoted by B; and the number of fine particles having a size of 10 &#x3bc;m or more is 25 or less and the number of fine particles having a size of 25 &#x3bc;m or more is 3 or less in 1 mL of a physiological saline solution for injection both three months and six months after said physiological saline solution for injection is sealed in the blood purification device.

A plasma purification membrane and a plasma purification system for treating diseases. The above plasma purification membrane is a hollow fiber plasma purification membrane being made of a hydrophobic polymer and a hydrophilic polymer and having a sponge-like structure wherein the pore size is continuously decreased from the outer surface of the membrane toward the inner surface thereof, characterized in that the break strength of the membrane is 50 kgf/cmor more and, in the case of the inner pressure filtration of bovine plasma, the total protein permeability is 50% or more while the immunoglobulin (IgM) permeability is 90% or less.

Plasma purification membrane and plasma purification system

A filter for reducing leukocytes and platelets from an erythrocyte preparation or a whole blood preparation which is characterized by having a filter base coated with a polymer, the content of the polymer being from 0.5 to 10 mg/mper unit area of the total surface of the filter base, and the polymer containing 20% or less of low-molecular weight components having a molecular weight not more than &#xbc; of the peak top molecular weight in the gel permeation chromatogram.

Filter for processing blood and process for producing the same

It is intended to provide a blood purification membrane having excellent performance and showing little elution of blood and little adhesion of blood proteins or platelets. The above object can be achieved by using a moisten membrane, which is free from any membrane pore-sustaining agent and has a high water permeation dose and a large pore size, and lessening the pore size by drying the membrane after desolvation.

Hollow fiber membrane for purifying blood

A filter for selectively removing leukocytes from the human whole blood, characterized in that it comprises a filter base coated with a hydrophilic synthetic polymer having a weight-average molecular weight of 300,000 to 3,000,000 and that the percentage of covering by the polymer is 70% or higher based on the whole surface of the filter base.

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Miyazaki, Japan

Teruhiko Oishi