Seed Research Institute Co., Ltd.

Op Bio Factory Co., Ltd.

Okayama University

Kinki University

Microbial Chemistry Research Foundation

Teruhiko Ishikawa

Morita Iwami

Masayuki Igarashi

Ryutaro Utsumi

Kotaro Suto

Takayuki Kudoh

Shyota Katayama

Hironori Nishiuchi

Yoshikuni Itoh

Makoto Okada

Masatoshi Taniguchi

Tatsuya Kitaoka

Seiki Saito

Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.

Method for producing kakeromycin and derivatives thereof

Provided is an antifungal composition containing a cyclic N-sulfonylamine compound, a cyclic N-sulfonylimine compound or a cyclic N-sulfonyloxaziridine compound, each having an antifungal activity, as an active ingredient. An antifungal composition containing a compound represented by the formula (1): wherein

Antifungal composition

Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein

Oxaziridine compound and production method thereof

The present invention provides compounds belonging to 3-acyloxyindole compounds or 3-acyl-4-hydroxycoumarin compounds, a tautomer or geometric isomer thereof, or a salt thereof and methods for producing the same, which compounds are useful as antibacterial agent and as therapeutic drugs against infectious diseases.

Compound; tautomer and geometric isomer thereof; salt of said compound, tautomer, or geometric isomer; method for manufacturing said compound, tautomer, isomer, or salt; antimicrobial agent; and anti-infective drug

It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4): (wherein R, Rand Rare same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and Rand Rare not methyl simultaneously).

Nitro group-containing ether compound and method for producing same

Growing community of inventors

Okayama, Japan

Teruhiko Ishikawa