Fujisawa Pharmaceutical Company, Ltd.

Teruaki Matuo

Yoshinari Sato

Takatomo Ogahara

Takao Takaya

Kazuo Sakane

Kenzi Miyai

The invention relates to novel cholecystokinin antagonists of the formula ##STR1## wherein R.sup.1 is aryl or substituted aryl, and a pharmaceutically acceptable salt thereof useful as cholecystokinin antagonists.

Tricyclic compounds having cholecystokinin antagonist activity

The invention relates to a compound of the formula ##STR1## wherein R.sup.1 is aryl which may have suitable substituent(s), X is --O-- or ##STR2## in which R.sup.3 is hydrogen or lower alkyl, A is a bond or lower alkylene which may have lower alkyl group(s), and R.sup.2 is arylcarbamoyl which may have halogen or lower alkoxy, or a pharmaceutically acceptable salt thereof, useful as a cholecystokinin antagonist.

Tricyclic compounds

Intermediates of the formula: ##STR1## wherein R.sup.1 is tetrazolyl or imidazolyl, each of which may have an imino protective group,

Benzodiazepine derivatives

Tricyclic benzodiazepine derivates, their preparation, and

A compound of the formula ##STR1## the process for its preparation and intermediate thereof. The compound is useful as a cholecystokinin antagonist.

The invention relates to novel cholecystokinin antagonists of the formula ##STR1## wherein R.sup.1 is aryl which may have suitable substituent(s), X is --O-- or ##STR2## in which R.sup.3 is hydrogen or lower alkyl, A is bond; or methylene, ethylene, trimethylene, tetramethylene, pentamethylene or hexamethylene, each of which may have lower alkyl group(s), and

The invention relates to a compound of the formula: ##STR1## wherein R.sup.1 is aryl which may have suitable substituents(s), X is --O-- or ##STR2## in which R.sup.3 is hydrogen or lower alkyl, A is a bond or lower alkylene which may have lower alkyl group(s), and

Tricyclo benzodiazepines are cholecystokinin antagonists.

This invention relates to new benzodiazepine derivatives and pharmaceutically acceptable salts thereof. More particularly, it relates to new benzodiazepine derivatives and pharmaceutically acceptable salts thereof which are cholecystokinin (CCK) antagonists and therefore can be used as therapeutical agents for emesis, pancreatitis, satiety and appetite control, pain control, insulinoma, gastroparesis, acute obstructive cholecystitis, irritable bowel disease, carcinoma of pancreas, etc.

The invention relates to antimicrobial compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,

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Osaka, Japan

Teruaki Matuo